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Literature summary extracted from

  • Yamamoto, K.; Katsuda, N.; Himeno, M.; Kato, K.
    Cathepsin D of rat spleen. Affinity purification and properties of two types of cathepsin D (1979), Eur. J. Biochem., 95, 459-467.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.5 Fe3+
-
Rattus norvegicus
3.4.23.5 Pb2+ cathepsin D-II inhibited, cathepsin D-I hardly affected Rattus norvegicus
3.4.23.5 PCMB
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.23.5 Zn2+ slight activation of cathepsin D-II Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.5 44000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.5 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.5 side-chain modification cathepsin D-I: neutral sugar content 6%, contains mannose, glucose, galactose, fucose and glucosamine in a ratio of 8:2:1:1:5 Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.5 affinity purification, 2 enzyme forms, the major form is termed cathepsin D-1, the minor form is termed cathepsin D-II Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.5 spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.23.5 additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.5 Albumin + H2O bovine serum albumin Rattus norvegicus ?
-
?
3.4.23.5 Albumin + H2O human serum albumin Rattus norvegicus ?
-
?
3.4.23.5 Hemoglobin + H2O
-
Rattus norvegicus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.23.5 monomer 1 * 44000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.5 45
-
cathepsin D-II Rattus norvegicus
3.4.23.5 55
-
cathepsin D-I Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.23.5 37
-
pH 7.0, 90 min, 40% loss of activity Rattus norvegicus
3.4.23.5 60
-
10 min, pH 3.8 or pH 7.0, loss of a large portion of activity of enzyme form cathepsin D-I and cathepsin D-II Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.23.5 3.8
-
10 min, 60°C, loss of a large portion of activity of enzyme form cathepsin D-I and cathepsin D-II Rattus norvegicus
3.4.23.5 7
-
10 min, 60°C, loss of a large portion of activity of enzyme form cathepsin D-I and cathepsin D-II Rattus norvegicus
3.4.23.5 7
-
37°C, 90 min, 40% loss of activity Rattus norvegicus