Literature summary extracted from

Sebti, S.M.; Mignano, J.E.; Jani, J.P.; Srimatkandada, S.; Lazo, J.S.
Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family (1989), Biochemistry, 28, 6544-6548.

Application

EC Number	Application	Comment	Organism
3.4.22.40	medicine	-	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.40	1-(L-trans-epoxysuccinylleucylamino)-4-guanidinobutane	-	Homo sapiens
3.4.22.40	1-(L-trans-epoxysuccinylleucylamino)-4-guanidinobutane	-	Oryctolagus cuniculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.40	Gallus gallus	-	-	-
3.4.22.40	Homo sapiens	-	-	-
3.4.22.40	Lithobates catesbeianus	-	bullfrog	-
3.4.22.40	Mus musculus	-	-	-
3.4.22.40	Oryctolagus cuniculus	-	-	-
3.4.22.40	Papio hamadryas	-	baboon	-
3.4.22.40	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.40	liver	-	Oryctolagus cuniculus	-
3.4.22.40	lung	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.40	bleomycin + H2O	bleomycin A2	Gallus gallus	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Mus musculus	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Homo sapiens	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Rattus norvegicus	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Oryctolagus cuniculus	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Lithobates catesbeianus	deamido-bleomycin	-	?
3.4.22.40	bleomycin + H2O	bleomycin A2	Papio hamadryas	deamido-bleomycin	-	?

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Release 2023.1 (January 2023)