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Literature summary extracted from

  • Deval, C.; Bechet, D.; Obled, A.; Ferrara, M.
    Purification and properties of different isoforms of bovine cathepsin B (1990), Biochem. Cell Biol., 68, 822-826.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.1 cysteine activates Bos taurus
3.4.22.1 dithiothreitol activates Bos taurus
3.4.22.1 thiol compounds
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane E-64 Bos taurus
3.4.22.1 leupeptin
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.1 0.114 0.125 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.1 25000
-
 1 * 25000 + 1 * 5000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Proteins + H2O Bos taurus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.1
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Bos taurus benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Bos taurus carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 Proteins + H2O
-
 Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.1 dimer 1 * 25000 + 1 * 5000, SDS-PAGE Bos taurus
3.4.22.1 dimer heavy and light chain result from cleavage of mature cathepsin B Bos taurus
3.4.22.1 monomer 1*30000, SDS-PAGE Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.22.1 52 75 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.1 4.5 7
-
 Bos taurus