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Literature summary extracted from

  • Marquet, A.; Nieto, M.; Diaz-Maurino, T.
    Membrane-bound DD-carboxypeptidase and transpeptidase activities from Bacillus megaterium KM at pH 7. General properties, substrate specificity and inhibition by beta-lactam antibiotics (1976), Eur. J. Biochem., 68, 581-589.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.16.4 2-mercaptoethanol activation Priestia megaterium
3.4.16.4 p-chloromercuribenzoate stimulation of hydrolase reaction, no influence on transpeptidase Priestia megaterium

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.16.4 Ca2+
-
 Priestia megaterium
3.4.16.4 cephalosporidin
-
 Priestia megaterium
3.4.16.4 Co2+
-
 Priestia megaterium
3.4.16.4 Cu2+
-
 Priestia megaterium
3.4.16.4 D-Ala
-
 Priestia megaterium
3.4.16.4 diacetyl-L-Lys-D-Ala
-
 Priestia megaterium
3.4.16.4 Dicloxacillin
-
 Priestia megaterium
3.4.16.4 Hg2+
-
 Priestia megaterium
3.4.16.4 Mg2+
-
 Priestia megaterium
3.4.16.4 Pb2+
-
 Priestia megaterium
3.4.16.4 penicillin G
-
 Priestia megaterium

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.16.4 membrane
-
 Priestia megaterium 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.16.4 additional information no cation requirement Priestia megaterium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Priestia megaterium
-
 ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Priestia megaterium KM / ATCC 13632
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.4 Priestia megaterium
-
 KM
-
3.4.16.4 Priestia megaterium KM / ATCC 13632
-
 KM
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Priestia megaterium Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Priestia megaterium KM / ATCC 13632 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Priestia megaterium ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Priestia megaterium KM / ATCC 13632 ?
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Priestia megaterium UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Priestia megaterium KM / ATCC 13632 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.16.4 40
-
-
 Priestia megaterium

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.16.4 40
-
 inactivation above Priestia megaterium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.16.4 7
-
-
 Priestia megaterium