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Literature summary extracted from

  • Shimamori, Y.; Watanabe, Y.; Fujimoto, Y.
    Human placental dipeptidyl aminopeptidase III: Hydrolysis of enkephalins and its stimulation by cobaltus ions (1988), Biochem. Med. Metab. Biol., 40, 305-310.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.4 5,5'-dithiobis(2-nitrobenzoate)
-
 Homo sapiens
3.4.14.4 p-chloromercuribenzoate not with Leu-enkephalin as substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.4 0.081
-
 Leu-enkephalin
-
 Homo sapiens
3.4.14.4 0.22
-
 Leu-enkephalin with Co2+ Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.4 Co2+ increase of activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.4 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.4 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.4 Arg-Arg-2-naphthylamide + H2O
-
 Homo sapiens Arg-Arg + 2-naphthylamine
-
 ?
3.4.14.4 Arg-Arg-4-methoxy-2-naphthylamide + H2O
-
 Homo sapiens Arg-Arg + 4-methoxy-2-naphthylamine
-
 ?
3.4.14.4 Leu-enkephalin + H2O
-
 Homo sapiens Tyr-Gly + Gly-Phe-Leu
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.4 7.5
-
 substrate Leu-enkephalin Homo sapiens
3.4.14.4 9
-
 substrate Arg-Arg-p-nitroanilide or Arg-Arg-2-naphthylamide Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.14.4 5 9 depending on substrate Homo sapiens