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Literature summary extracted from

  • McDonald, J.K.; Callahan, P.X.; Zeitman, B.B.; Ellis, S.
    Inactivation and degradation of glucagon by dipeptidyl aminopeptidase I (cathepsin C) of rat liver (1969), J. Biol. Chem., 244, 6199-6208.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.14.1 sulfhydryl activators required Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.1 glucagon competitive inhibition of His-Ser-2-naphthylamide hydrolysis Rattus norvegicus
3.4.14.1 Gly-Phe-NH2 competitive inhibition of His-Ser-2-naphthylamide hydrolysis Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.1 0.022
-
 His-Ser-2-naphthylamide
-
 Rattus norvegicus
3.4.14.1 0.027
-
 glucagon removal of His-Ser Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.1 Cl- required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.1
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.1 glucagon + H2O
-
 Rattus norvegicus His-Ser + Thr-Phe + Thr-Ser + Asp-Tyr + Ser-Lys + Tyr-Leu + Asp-Ser + ? further degradation of the hormone is prevented by the appearance of the NH2-terminal Arg ?
3.4.14.1 His-Ser-2-naphthylamide + H2O
-
 Rattus norvegicus His-Ser + 2-naphthylamine
-
 ?
3.4.14.1 secretin + H2O
-
 Rattus norvegicus His-Ser + Asp-Gly + Thr-Phe + Thr-Ser + Glu-Leu + Ser-Arg + Leu-Arg + Asp-Ser + Ala-Arg + Leu-Gln + ? further degradation of the hormone is prevented by the appearance of the NH2-terminal Arg ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.14.1 81
-
 glucagon removal of His-Ser Rattus norvegicus
3.4.14.1 116
-
 His-Ser-2-naphthylamide
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.1 5.2
-
 His-Ser-beta-naphthylamide as substrate Rattus norvegicus
3.4.14.1 6.3
-
 removal of His-Ser from glucagon Rattus norvegicus