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Literature summary extracted from

  • Orawski, A.T.; Susz, J.P.; Simmons, W.H.
    Aminopeptidase P from bovine lung: solubilization, properties, and potential role in bradykinin degradation (1987), Mol. Cell. Biochem., 75, 123-132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.9 1,10-phenanthroline
-
 Bos taurus
3.4.11.9 2-mercaptoethanol
-
 Bos taurus
3.4.11.9 4-chloromercuriphenyl sulfonic acid inhibits cleavage of Arg-Pro-Pro Bos taurus
3.4.11.9 amastatin
-
 Bos taurus
3.4.11.9 diisopropylphosphofluoridate
-
 Bos taurus
3.4.11.9 PCMB inhibits cleavage of Arg-Pro-Pro Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.9 0.93
-
 Arg-Pro-Pro
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.9 additional information Bos taurus the enzyme may have an important role in the pulmonary degradation of the potent vasoactive peptide, bradykinin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.9 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.9 lung
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.9 Arg-Pro-Pro + H2O
-
 Bos taurus Arg + Pro-Pro
-
 ?
3.4.11.9 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
 Bos taurus Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
 ?
3.4.11.9 Gly-Pro-Hyp + H2O
-
 Bos taurus Gly + Pro-Hyp
-
 ?
3.4.11.9 additional information the enzyme may have an important role in the pulmonary degradation of the potent vasoactive peptide, bradykinin Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.9 7
-
 hydrolysis of Arg-Pro-Pro Bos taurus