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Literature summary extracted from

  • Lloyd, G.S.; Hryszko, J.; Hooper, N.M.; Turner, A.J.
    Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate (1996), Biochem. Pharmacol., 52, 229-236.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.9 4-chloromercuriphenyl sulfonic acid inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.9 4-chloromercuriphenyl sulfonic acid inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin Sus scrofa
3.4.11.9 bradykinin hydrolysis of Gly-Pro-Hyp Sus scrofa
3.4.11.9 cilazaprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methyl-7-coumarylamide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa
3.4.11.9 enaprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa
3.4.11.9 Mn2+ above, 0.01 mM, hydrolysis of bradykinin and Arg-Pro-Pro Sus scrofa
3.4.11.9 ramiprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P or beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.9 2.7
-
Gly-Pro-Hyp
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.9 Mn2+ 4-10 mM, activates hydrolysis of Gly-Pro-Hyp, beta-casomorphin or substance P Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.9 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.9
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.9 kidney brush border membrane Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.9 Arg-Pro-Pro + H2O
-
Sus scrofa Arg + Pro-Pro
-
?
3.4.11.9 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
Sus scrofa Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
?
3.4.11.9 beta-casomorphin + H2O
-
Sus scrofa ?
-
?
3.4.11.9 Gly-Pro-Hyp + H2O
-
Sus scrofa Gly + Pro-Hyp
-
?
3.4.11.9 Substance P + H2O
-
Sus scrofa ?
-
?