Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, K.C.S.; Buchanan, T.M.
    Hydrolases from Neisseria gonorrhoeae. The study of gonocosin, an aminopeptidase-P, a proline iminopeptidase, and an asparaginase (1980), J. Biol. Chem., 255, 1704-1710.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.5 dithiothreitol activity enhancement Neisseria gonorrhoeae

General Stability

EC Number General Stability Organism
3.4.11.9 complete loss of activity after dialysis Neisseria gonorrhoeae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.5 Cd2+
-
 Neisseria gonorrhoeae
3.4.11.5 Hg2+
-
 Neisseria gonorrhoeae
3.4.11.5 N-ethylmaleimide
-
 Neisseria gonorrhoeae
3.4.11.5 p-chloromercuribenzoate
-
 Neisseria gonorrhoeae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.9 Cd2+ activates Neisseria gonorrhoeae
3.4.11.9 Co2+ metal ion required, Co2+ is the best activator Neisseria gonorrhoeae
3.4.11.9 Mn2+ activates Neisseria gonorrhoeae

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.5 Neisseria gonorrhoeae
-
-
-
3.4.11.9 Neisseria gonorrhoeae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.5 L-prolyl-peptide + H2O hydrolytic activity decreases with increasing chain length Neisseria gonorrhoeae L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Neisseria gonorrhoeae L-proline + peptide
-
 ?
3.4.11.9 Ala-Pro + H2O
-
 Neisseria gonorrhoeae Ala + Pro
-
 ?
3.4.11.9 Ala-Pro-Gly + H2O
-
 Neisseria gonorrhoeae Ala + Pro-Gly
-
 ?
3.4.11.9 Gly-Pro + H2O
-
 Neisseria gonorrhoeae Gly + Pro
-
 ?
3.4.11.9 Gly-Pro-Ala + H2O
-
 Neisseria gonorrhoeae Gly + Pro-Ala
-
 ?
3.4.11.9 Gly-Pro-Gly-Gly + H2O
-
 Neisseria gonorrhoeae Gly + Pro-Gly-Gly
-
 ?
3.4.11.9 Gly-Pro-Hyp + H2O
-
 Neisseria gonorrhoeae Gly + Pro-Hyp
-
 ?
3.4.11.9 Leu-Pro + H2O
-
 Neisseria gonorrhoeae Leu + Pro
-
 ?
3.4.11.9 Leu-Pro-Gly-Gly + H2O
-
 Neisseria gonorrhoeae Leu + Pro-Gly-Gly
-
 ?
3.4.11.9 Met-Pro + H2O
-
 Neisseria gonorrhoeae Met + Pro
-
 ?
3.4.11.9 additional information the enzyme releases only amino acid X from the NH2-termini of peptides with the general structure X-Pro-Y-Z Neisseria gonorrhoeae ?
-
 ?
3.4.11.9 Phe-Pro + H2O
-
 Neisseria gonorrhoeae Phe + Pro
-
 ?
3.4.11.9 Pro-Pro + H2O
-
 Neisseria gonorrhoeae Pro
-
 ?
3.4.11.9 Ser-Pro + H2O
-
 Neisseria gonorrhoeae Ser + Pro
-
 ?
3.4.11.9 Val-Pro + H2O
-
 Neisseria gonorrhoeae Val + Pro
-
 ?