Any feedback?
Literature summary extracted from
- A highly specific aminotripeptidase of rat brain cytosol. Substrate specificity and effects of inhibitors (1982), Biochim. Biophys. Acta, 706, 229-238.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.4 | antipain | - |
Rattus norvegicus |  |
| 3.4.11.4 | bestatin | - |
Rattus norvegicus | |
| 3.4.11.4 | Cd2+ | - |
Rattus norvegicus | |
| 3.4.11.4 | chymostatin | - |
Rattus norvegicus | |
| 3.4.11.4 | Cu2+ | - |
Rattus norvegicus | |
| 3.4.11.4 | D-3-thio-2-methylpropanyl proline | - |
Rattus norvegicus | |
| 3.4.11.4 | iodoacetate | - |
Rattus norvegicus | |
| 3.4.11.4 | L-Leu | - |
Rattus norvegicus | |
| 3.4.11.4 | L-Leu-Gly-Gly | substrate inhibition | Rattus norvegicus | |
| 3.4.11.4 | Met-enkephalin | - |
Rattus norvegicus | |
| 3.4.11.4 | Met-Leu-Tyr | - |
Rattus norvegicus | |
| 3.4.11.4 | N-ethylmaleimide | - |
Rattus norvegicus | |
| 3.4.11.4 | Pb2+ | - |
Rattus norvegicus | |
| 3.4.11.4 | Phenylmethanesulfonylfluoride | - |
Rattus norvegicus | |
| 3.4.11.4 | tosyl-phenylalanine-chloromethylketone | - |
Rattus norvegicus | |
| 3.4.11.4 | Tripeptides with Pro in N-terminal position | - |
Rattus norvegicus | |
| 3.4.11.4 | Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.4 | 0.4 | - |
Leu-Gly-Gly | - |
Rattus norvegicus | |
| 3.4.11.4 | 0.9 | - |
Phe-Gly-Gly | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.4 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.4 | tripeptides + H2O | Rattus norvegicus | e.g. Met-Leu-Tyr: chemotactic factor, Gly-His-Lys: liver growth factor, slow hydrolysis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.4 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.11.4 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.4 | brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.4 | 73.5 | - |
- |
Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.4.11.4 | -20°C, 100 mM potassium phosphate buffer, pH 7.6, 0.05 M dithiothreitol, 50% glycerol | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.4 | L-Phe-Gly-Gly + H2O | - |
Rattus norvegicus | L-Phe + Gly-Gly | - |
? | |
| 3.4.11.4 | Leu-Gly-Gly + H2O | Leu can be replaced by Ala, Phe, Gly-Pro | Rattus norvegicus | Leu + Gly-Gly | - |
? | |
| 3.4.11.4 | additional information | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.11.4 | tripeptides + H2O | e.g. Met-Leu-Tyr: chemotactic factor, Gly-His-Lys: liver growth factor, slow hydrolysis | Rattus norvegicus | ? | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
