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Literature summary extracted from

  • Cornell, J.S.
    Oxytocinase (L-cystine aminopeptidase) from term human placenta (1980), Biochem. Int., 1, 10-18.
No PubMed abstract available

General Stability

EC Number General Stability Organism
3.4.11.3 freeze-thawing, stable Homo sapiens
3.4.11.3 lyophilization, stable Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.3 1,10-phenanthroline
-
 Homo sapiens
3.4.11.3 Cd2+
-
 Homo sapiens
3.4.11.3 Cu2+
-
 Homo sapiens
3.4.11.3 NaCN
-
 Homo sapiens
3.4.11.3 Pb2+ inhibits at pH 6.0, not at pH 7.4 Homo sapiens
3.4.11.3 Zn2+ inhibition at pH 6.0 not at pH 7.5 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.3 0.29
-
 S-benzyl-L-cysteine-p-nitroanilide pH 6.0 Homo sapiens
3.4.11.3 0.36
-
 leucyl-p-nitroanilide pH 7.4 Homo sapiens
3.4.11.3 0.45
-
 S-benzyl-L-cysteine-p-nitroanilide pH 7.4 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.3 24000
-
 isoenzyme I, x * 24000, SDS-PAGE Homo sapiens
3.4.11.3 30000
-
 x * 30000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.3 Homo sapiens
-
 2 forms: I, II
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.3 side-chain modification
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.3
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.3 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.11.3 52
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.4.11.3 -15°C, 0.01 M potassium phosphate, pH 7.4, protein concentration 0.5 mg/ml, 6 months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.3 additional information glycyl-p-nitroanilide Homo sapiens ?
-
 ?
3.4.11.3 oxytocin + H2O
-
 Homo sapiens acyclic peptide + H2O
-
 ?
3.4.11.3 S-benzyl-L-cysteine-p-nitroanilide + H2O
-
 Homo sapiens S-benzyl-L-cysteine + p-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.11.3 ? x * 30000, SDS-PAGE Homo sapiens
3.4.11.3 ? isoenzyme I, x * 24000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.3 6
-
 form I Homo sapiens
3.4.11.3 7.4
-
 form II Homo sapiens