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Literature summary extracted from

  • Gros, C.; Giros, B.; Schwartz, J.C.
    Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes (1985), Biochemistry, 24, 2179-2185.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 bestatin Ki: 0.004 mM Rattus norvegicus
3.4.11.2 EDTA 60-80% inhibition at 20 mM Rattus norvegicus
3.4.11.2 puromycin Ki: 0.1 mM, low sensitivity to puromycin Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.2 0.02
-
 Leu-2-naphthylamide from brain Rattus norvegicus
3.4.11.2 0.025
-
 L-Arg-2-naphthylamide from kidney Rattus norvegicus
3.4.11.2 0.027
-
 L-Arg-2-naphthylamide from brain Rattus norvegicus
3.4.11.2 0.027
-
 Leu-2-naphthylamide from kidney Rattus norvegicus
3.4.11.2 0.038
-
 Ala-2-naphthylamide from kidney Rattus norvegicus
3.4.11.2 0.04
-
 Ala-2-naphthylamide from brain Rattus norvegicus
3.4.11.2 0.045
-
 Leu5-enkephalin from brain Rattus norvegicus
3.4.11.2 0.045
-
 Met5-enkephalin from brain Rattus norvegicus
3.4.11.2 0.06
-
 Met5-enkephalin from kidney Rattus norvegicus
3.4.11.2 0.065
-
 Leu5-enkephalin from kidney Rattus norvegicus
3.4.11.2 0.8
-
 Gly-2-naphthylamide from brain Rattus norvegicus
3.4.11.2 1
-
 Gly-2-naphthylamide from kidney Rattus norvegicus
3.4.11.2 2.1 2.9 Phe-Gly
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane cerebral membrane Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Cd2+ reactivation after inhibition by EDTA Rattus norvegicus
3.4.11.2 Co2+ reactivation after inhibition by EDTA Rattus norvegicus
3.4.11.2 Mn2+ reactivation after inhibition by EDTA Rattus norvegicus
3.4.11.2 Zn2+ reactivation after inhibition by EDTA Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.2 aminoacyl peptide Rattus norvegicus
-
 ?
-
 ?
3.4.11.2 enkephalin Rattus norvegicus may be involved in enkephalin neurotransmitter inactivation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 brain
-
 Rattus norvegicus
-
3.4.11.2 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 aminoacyl peptide
-
 Rattus norvegicus ?
-
 ?
3.4.11.2 aminoacyl-2-naphthylamide + H2O
-
 Rattus norvegicus amino acid + 2-naphthylamine
-
 ?
3.4.11.2 enkephalin may be involved in enkephalin neurotransmitter inactivation Rattus norvegicus ?
-
 ?
3.4.11.2 Gly-2-naphthylamide + H2O
-
 Rattus norvegicus Gly + 2-naphthylamine
-
 ?
3.4.11.2 L-Arg-2-naphthylamide + H2O
-
 Rattus norvegicus L-Arg + 2-naphthylamine
-
 ?
3.4.11.2 Leu-2-naphthylamide + H2O
-
 Rattus norvegicus Leu + 2-naphthylamine
-
 ?
3.4.11.2 Leu5-enkephalin + H2O
-
 Rattus norvegicus tyrosin + (2-5)Leu5-enkephalin
-
 ?
3.4.11.2 Met5-enkephalin + H2O
-
 Rattus norvegicus tyrosin + (2-5)Met5-enkephalin
-
 ?
3.4.11.2 Phe-Gly + H2O
-
 Rattus norvegicus Phe + Gly
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.2 0.004
-
 bestatin
-
 Rattus norvegicus