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Literature summary extracted from

  • Taoka, S.; Padmakumar, R.; Lai, M.; Liu, H.; Banerjee, R.
    Inhibition of the human methylmalonyl-CoA mutase by various CoA-esters (1994), J. Biol. Chem., 269, 31630-31634.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.2 Cyclopropylcarbonyl-CoA carboxylate reversible mixed-type inhibition Homo sapiens
5.4.99.2 methylenecyclopropylacetyl-CoA reversible mixed-type inhibition Homo sapiens
5.4.99.2 methylmalonyl-CoA reversible mixed-type inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.2 0.06
-
 (R/S)-2-methyl-3-oxopropanoyl-CoA
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.2 Homo sapiens
-
 expressed in Saccharomyces cerevisiae
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.2 expressed in Saccharomyces cerevisiae Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.4.99.2 67.4
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
 Homo sapiens succinyl-CoA
-
 ?
5.4.99.2 (R/S)-2-methyl-3-oxopropanoyl-CoA
-
 Homo sapiens succinyl-CoA
-
 ?
5.4.99.2 ethylmalonyl-CoA reacts about 1000-10000 times moreslowly than the natural substrate Homo sapiens methylsuccinyl-CoA
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.4.99.2 150
-
 (R/S)-2-methyl-3-oxopropanoyl-CoA 30°C Homo sapiens
5.4.99.2 283
-
 (R/S)-2-methyl-3-oxopropanoyl-CoA 37°C Homo sapiens