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Literature summary extracted from

  • Buttle, D.J.; Bonner, B.C.; Burnett, D.; Barrett, A.J.
    A catalytically active high-Mr form of human cathepsin B from sputum (1988), Biochem. J., 254, 693-699.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 cystatin Ki: 29 nM Homo sapiens
3.4.22.1 L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane E-64 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.1 0.046
-
 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens
3.4.22.1 0.071
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.1 37000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Proteins + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.1 side-chain modification glycoprotein Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.1 partially Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 sputum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.1 0.693
-
 benzyloxycarbonyl-Arg-Arg-beta-naphthylamide as substrate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
-
 Homo sapiens benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
 ?
3.4.22.1 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
-
 Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 Proteins + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.1 5.5
-
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.1 0.000029
-
 cystatin
-
 Homo sapiens