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Literature summary extracted from

  • Ohshima, T.; Soda, K.
    Modification of leucine dehydrogenase by pyridoxal 5'-phosphate (1984), Agric. Biol. Chem., 48, 349-354.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.9 pyridoxal 5'-phosphate fully protected from inactivation only by NADH Lysinibacillus sphaericus

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.9 Lysinibacillus sphaericus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.9 L-Leu + H2O + NAD+
-
 Lysinibacillus sphaericus 4-methyl-2-oxopentanoate + NH3 + NADH
-
 r
1.4.1.9 L-Val + H2O + NAD+
-
 Lysinibacillus sphaericus 3-methyl-2-oxobutanoate + NH3 + NADH
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.1.9 9 9.5 reductive amination of 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate, phosphopyridoxylated enzyme Lysinibacillus sphaericus
1.4.1.9 10.5 10.8 oxidative deamination of L-Leu and L-Val, phosphopyridoxylated enzyme Lysinibacillus sphaericus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.9 NAD+
-
 Lysinibacillus sphaericus
1.4.1.9 NADH
-
 Lysinibacillus sphaericus