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Literature summary extracted from

  • Jacobs, J.M.; Sinclair, P.R.; Sinclair, J.F.; Gorman, N.; Walton, H.S.; Wood, S.G.; Nichols, C.
    Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead (1998), Toxicology, 125, 95-105.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.98.1.1 2,2'-dipyridyl
-
 Rattus norvegicus
4.98.1.1 N-methylmesoporphyrin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.98.1.1 protoporphyrin IX + Fe2+ Gallus gallus final step of heme biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.98.1.1 Gallus gallus
-
-
-
4.98.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.98.1.1 hepatocyte embryonal, cultured Gallus gallus
-
4.98.1.1 hepatocyte embryonal, cultured Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.98.1.1 protoporphyrin + Fe2+
-
 Gallus gallus protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin + Fe2+
-
 Rattus norvegicus protoheme + 2 H+
-
 ?
4.98.1.1 protoporphyrin + Zn2+
-
 Rattus norvegicus Zn2+-protoporphyrin + H+
-
 ?
4.98.1.1 protoporphyrin IX + Fe2+ final step of heme biosynthesis Gallus gallus ?
-
 ?