Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Podschun, B.
    Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver (1992), Biochem. Biophys. Res. Commun., 182, 609-616.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.2 medicine rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.2
-
 Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.2 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ abstraction of pro-S hydrogen of NADPH and thus B-side stereospecific class dehydrogenase Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 uracil + NADPH
-
 Sus scrofa 5,6-dihydrouracil + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADPH strictly dependent on Sus scrofa