Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Podschun, B.; Cook, P.F.; Schnackerz, K.D.
    Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver (1990), J. Biol. Chem., 265, 12966-12972.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 5,6-Dihydropyrimidine
-
 Sus scrofa
1.3.1.2 NADPH
-
 Sus scrofa
1.3.1.2 Uracil
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.2 0.001
-
 Uracil
-
 Sus scrofa
1.3.1.2 0.007
-
 NADPH
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 thymine + NADPH Sus scrofa
-
 dihydrothymine + NADP+
-
 ?
1.3.1.2 uracil + NADPH Sus scrofa
-
 5,6-dihydrouracil + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.2 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ nonclassical ping-pong mechanism Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 thymine + NADPH
-
 Sus scrofa dihydrothymine + NADP+
-
 ?
1.3.1.2 uracil + NADPH
-
 Sus scrofa 5,6-dihydrouracil + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.2 37
-
 assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADP+
-
 Sus scrofa
1.3.1.2 NADPH
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.2 additional information
-
 additional information inhibitory reactions between uracil, NADP+ and dihydrouracil Sus scrofa