EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | AMP | stimulates 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | GMP | activates 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | GTP | activates 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | UDP | activates 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | UTP | activates 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | ATP | 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | NADH | - |
Dictyostelium discoideum | |
1.2.1.105 | succinyl-CoA | - |
Dictyostelium discoideum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.105 | 1 | - |
2-oxoglutarate | - |
Dictyostelium discoideum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.105 | mitochondrion | - |
Dictyostelium discoideum | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.105 | Dictyostelium discoideum | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.105 | 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) | Dictyostelium discoideum | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Dictyostelium discoideum |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.105 | additional information | tenfold increase in 2-oxoglutarate dehydrogenase complex activity between the amoeba stage and the aggregation stage, 2fold increase between the aggregation stage and the sorocarp stage | Dictyostelium discoideum | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.105 | additional information | - |
specific activity of the 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Dictyostelium discoideum | S-succinyldihydrolipoamide + CO2 | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.105 | 8 | 8.5 | 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.105 | 0.004 | - |
succinyl-CoA | 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum | |
1.2.1.105 | 0.018 | - |
NADH | 2-oxoglutarate dehydrogenase complex | Dictyostelium discoideum |