Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bisswanger, H.
    Substrate specificity of the pyruvate dehydrogenase complex from Escherichia coli (1981), J. Biol. Chem., 256, 815-822.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 3-Bromopyruvate
-
Escherichia coli
1.2.1.104 acetaldehyde weak Escherichia coli
1.2.1.104 alpha-Ketobutyric acid
-
Escherichia coli
1.2.1.104 alpha-Ketocaproate
-
Escherichia coli
1.2.1.104 alpha-ketooctanoic acid
-
Escherichia coli
1.2.1.104 alpha-ketovalerate
-
Escherichia coli
1.2.1.104 beta-Hydroxypyruvate
-
Escherichia coli
1.2.1.104 Fluoropyruvate
-
Escherichia coli
1.2.1.104 glyoxylic acid weak Escherichia coli
1.2.1.104 L-lactate weak Escherichia coli
1.2.1.104 phenylpyruvate
-
Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 pyruvate + lipoamide Escherichia coli in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate S-acetyldihydrolipoamide + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + lipoamide in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate Escherichia coli S-acetyldihydrolipoamide + CO2
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.104 0.0014
-
Fluoropyruvate assay with whole enzyme complex Escherichia coli
1.2.1.104 0.028
-
Bromopyruvate assay with whole enzyme complex Escherichia coli
1.2.1.104 0.5
-
glyoxylic acid assay with whole enzyme complex Escherichia coli
1.2.1.104 1
-
beta-Hydroxypyruvate assay with whole enzyme complex Escherichia coli
1.2.1.104 2.25
-
alpha-Ketobutyric acid assay with whole enzyme complex Escherichia coli