EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.104 | 3-Bromopyruvate | - |
Escherichia coli | |
1.2.1.104 | acetaldehyde | weak | Escherichia coli | |
1.2.1.104 | alpha-Ketobutyric acid | - |
Escherichia coli | |
1.2.1.104 | alpha-Ketocaproate | - |
Escherichia coli | |
1.2.1.104 | alpha-ketooctanoic acid | - |
Escherichia coli | |
1.2.1.104 | alpha-ketovalerate | - |
Escherichia coli | |
1.2.1.104 | beta-Hydroxypyruvate | - |
Escherichia coli | |
1.2.1.104 | Fluoropyruvate | - |
Escherichia coli | |
1.2.1.104 | glyoxylic acid | weak | Escherichia coli | |
1.2.1.104 | L-lactate | weak | Escherichia coli | |
1.2.1.104 | phenylpyruvate | - |
Escherichia coli |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.104 | pyruvate + lipoamide | Escherichia coli | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate | S-acetyldihydrolipoamide + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.104 | Escherichia coli | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.104 | pyruvate + lipoamide | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate | Escherichia coli | S-acetyldihydrolipoamide + CO2 | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.104 | 0.0014 | - |
Fluoropyruvate | assay with whole enzyme complex | Escherichia coli | |
1.2.1.104 | 0.028 | - |
Bromopyruvate | assay with whole enzyme complex | Escherichia coli | |
1.2.1.104 | 0.5 | - |
glyoxylic acid | assay with whole enzyme complex | Escherichia coli | |
1.2.1.104 | 1 | - |
beta-Hydroxypyruvate | assay with whole enzyme complex | Escherichia coli | |
1.2.1.104 | 2.25 | - |
alpha-Ketobutyric acid | assay with whole enzyme complex | Escherichia coli |