EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | dihydrolipoyl transacetylase | - |
Bos taurus | |
2.7.11.2 | dihydrolipoyl transacetylase | rate-limiting in the holo-complex | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.1 | MgATP2- | due to phosphorylation of the enzyme by pyruvate dehydrogenase kinase | Sus scrofa | |
1.2.4.1 | phosphorylation | - |
Sus scrofa | |
2.7.11.2 | pyruvate | - |
Bos taurus | |
2.7.11.2 | pyruvate | - |
Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.4.1 | mitochondrion | - |
Sus scrofa | 5739 | - |
2.7.11.2 | mitochondrion | - |
Sus scrofa | 5739 | - |
2.7.11.2 | mitochondrion | - |
Bos taurus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | Mg2+ | requirement | Sus scrofa | |
2.7.11.2 | Mg2+ | requirement | Bos taurus | |
2.7.11.2 | Mg2+ | actual substrate: MgATP2- | Sus scrofa | |
2.7.11.2 | Mg2+ | actual substrate: MgATP2- | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.4.1 | 136000 | - |
gel filtration | Sus scrofa |
2.7.11.2 | 136000 | - |
pyruvate dehydrogenase, gel filtration | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | Sus scrofa | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.1 | Sus scrofa | - |
- |
- |
2.7.11.2 | Bos taurus | - |
- |
- |
2.7.11.2 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.2.4.1 | side-chain modification | inactivated by phosphorylation | Sus scrofa |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.2 | - |
Sus scrofa |
2.7.11.2 | kidney, from highly purifed pyruvate dehydrogenase-complex | Bos taurus |
2.7.11.2 | removed from the dihydrolipoyl transacetylase by treatment with p-hydroxymercuriphenylsulfonate | Bos taurus |
EC Number | Renatured (Comment) | Organism |
---|---|---|
1.2.4.1 | reconstitution of pyruvate dehydrogenase complex | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.1 | heart | - |
Sus scrofa | - |
1.2.4.1 | kidney | - |
Sus scrofa | - |
2.7.11.2 | heart | - |
Sus scrofa | - |
2.7.11.2 | heart | - |
Bos taurus | - |
2.7.11.2 | kidney | - |
Sus scrofa | - |
2.7.11.2 | kidney | - |
Bos taurus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.11.2 | 1.9 | 2.7 | purified enzyme, in presence of dihydrolipoyl transacetylase, reconstituted enzyme complex | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit | Sus scrofa | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Sus scrofa | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.11.2 | More | subunit composition and complex structure | Sus scrofa |
2.7.11.2 | More | subunit composition and complex structure | Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.2 | 30 | - |
assay at | Sus scrofa |
2.7.11.2 | 30 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.2 | 7 | - |
assay at | Sus scrofa |
2.7.11.2 | 7 | - |
assay at | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | ATP | dependent on | Sus scrofa | |
2.7.11.2 | ATP | dependent on | Bos taurus |