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Literature summary extracted from

  • Kerbey, A.L.; Randle, P.J.
    Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex) (1985), Biochem. J., 231, 523-529.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.2 dihydrolipoyl transacetylase
-
Bos taurus
2.7.11.2 dihydrolipoyl transacetylase rate-limiting in the holo-complex Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.1 MgATP2- due to phosphorylation of the enzyme by pyruvate dehydrogenase kinase Sus scrofa
1.2.4.1 phosphorylation
-
Sus scrofa
2.7.11.2 pyruvate
-
Bos taurus
2.7.11.2 pyruvate
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.1 mitochondrion
-
Sus scrofa 5739
-
2.7.11.2 mitochondrion
-
Sus scrofa 5739
-
2.7.11.2 mitochondrion
-
Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.2 Mg2+ requirement Sus scrofa
2.7.11.2 Mg2+ requirement Bos taurus
2.7.11.2 Mg2+ actual substrate: MgATP2- Sus scrofa
2.7.11.2 Mg2+ actual substrate: MgATP2- Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.4.1 136000
-
gel filtration Sus scrofa
2.7.11.2 136000
-
pyruvate dehydrogenase, gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Sus scrofa catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.1 Sus scrofa
-
-
-
2.7.11.2 Bos taurus
-
-
-
2.7.11.2 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.2.4.1 side-chain modification inactivated by phosphorylation Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.2
-
Sus scrofa
2.7.11.2 kidney, from highly purifed pyruvate dehydrogenase-complex Bos taurus
2.7.11.2 removed from the dihydrolipoyl transacetylase by treatment with p-hydroxymercuriphenylsulfonate Bos taurus

Renatured (Commentary)

EC Number Renatured (Comment) Organism
1.2.4.1 reconstitution of pyruvate dehydrogenase complex Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.1 heart
-
Sus scrofa
-
1.2.4.1 kidney
-
Sus scrofa
-
2.7.11.2 heart
-
Sus scrofa
-
2.7.11.2 heart
-
Bos taurus
-
2.7.11.2 kidney
-
Sus scrofa
-
2.7.11.2 kidney
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.2 1.9 2.7 purified enzyme, in presence of dihydrolipoyl transacetylase, reconstituted enzyme complex Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit Sus scrofa ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Sus scrofa ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Subunits

EC Number Subunits Comment Organism
2.7.11.2 More subunit composition and complex structure Sus scrofa
2.7.11.2 More subunit composition and complex structure Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.2 30
-
assay at Sus scrofa
2.7.11.2 30
-
assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.2 7
-
assay at Sus scrofa
2.7.11.2 7
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP dependent on Sus scrofa
2.7.11.2 ATP dependent on Bos taurus