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Literature summary extracted from

  • Senior, d.J.; Tasi, C.S.
    Purification and characterization of aldehyde dehydrogenase from rat liver mitochondria (1988), Arch. Biochem. Biophys., 262, 211-220.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.5 Chloral hydrate
-
 Rattus norvegicus
1.2.1.5 Disulfiram
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.5 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.5 60000
-
 4 * 60000, SDS-PAGE Rattus norvegicus
1.2.1.5 240000
-
 sucrose density gradient centrifugation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.5 0.212
-
 activity with NADP+ Rattus norvegicus
1.2.1.5 0.378
-
 activity with NAD+ Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.2.1.5 0-1°C, stable for 1 week Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 acetaldehyde + 3-pyridine aldehyde adenine dinucleotide phosphate
-
 Rattus norvegicus acetate + ?
-
 ?
1.2.1.5 acetaldehyde + acetylpyridine adenine dinucleotide
-
 Rattus norvegicus acetate + ?
-
 ?
1.2.1.5 acetaldehyde + deamino-NAD+ + H2O
-
 Rattus norvegicus acetate + deamino-NADH + H+
-
 ?
1.2.1.5 acetaldehyde + NAD+ + H2O
-
 Rattus norvegicus acetate + NADH + H+
-
 ?
1.2.1.5 acetaldehyde + NADP+ + H2O
-
 Rattus norvegicus acetate + NADPH + H+
-
 ?
1.2.1.5 acetaldehyde + thio-NAD+ + H2O
-
 Rattus norvegicus acetate + thio-NADH + H+
-
 ?
1.2.1.5 acetaldehyde + thio-NADP+
-
 Rattus norvegicus acetate + ?
-
 ?
1.2.1.5 formaldehyde + NAD+ + H2O
-
 Rattus norvegicus formate + NADH + H+
-
 ?
1.2.1.5 formaldehyde + NADP+ + H2O
-
 Rattus norvegicus formate + NADPH + H+
-
 ?
1.2.1.5 n-butanal + NAD+ + H2O
-
 Rattus norvegicus butanoate + NADH + H+
-
 ?
1.2.1.5 n-pentanal + NAD+ + H2O
-
 Rattus norvegicus n-pentanoate + NADH + H+
-
 ?
1.2.1.5 propanal + NAD+ + H2O
-
 Rattus norvegicus propionate + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.5 tetramer 4 * 60000, SDS-PAGE Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.5 55
-
 20 min, complete inactivation Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.5 6.4
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.5 6.2 6.7 pH 6.2: about 80% of maximal activity, pH 6.7: about 80% of maximal activity Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.5 0.012
-
 Disulfiram with respect to NADP+ Rattus norvegicus
1.2.1.5 0.069
-
 Disulfiram with respect to NAD+ Rattus norvegicus
1.2.1.5 0.19
-
 Chloral hydrate with respect to NAD+ Rattus norvegicus
1.2.1.5 0.2
-
 Chloral hydrate with respect to NADP+ Rattus norvegicus