EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.3 | mutant enzymes expressed in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.1.3 | E487K | mutant enzyme shows altered kinetic properties when compared to wild-type enzyme, The Km-value for NAD+ at pH 7.4 increases more than 150fold, the turnover-number decreases 2-10fold, many oriental people posses this variant of liver mitochondrial aldehyde dehydrogenase and have very low levels of enzyme activity | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.3 | 0.00008 | - |
propanal | native enzyme, pH 7.4 | Rattus norvegicus | |
1.2.1.3 | 0.0001 | - |
propanal | native enzyme, pH 9.0 | Rattus norvegicus | |
1.2.1.3 | 0.0002 | - |
propanal | mutant enzyme E487Q, pH 7.4 | Homo sapiens | |
1.2.1.3 | 0.0006 | - |
propanal | mutant enzyme E487K, pH 7.4 | Rattus norvegicus | |
1.2.1.3 | 0.0007 | - |
propanal | - |
Rattus norvegicus | |
1.2.1.3 | 0.0007 | - |
propanal | native enzyme, pH 7.4 | Homo sapiens | |
1.2.1.3 | 0.0014 | - |
propanal | mutant enzyme E487K, pH 7.4 | Homo sapiens | |
1.2.1.3 | 0.0017 | - |
propanal | mutant enzyme E487K, pH 9.0 | Rattus norvegicus | |
1.2.1.3 | 0.004 | - |
NAD+ | - |
Homo sapiens | |
1.2.1.3 | 0.004 | - |
NAD+ | native enzyme, pH 7.4 | Rattus norvegicus | |
1.2.1.3 | 0.07 | - |
NAD+ | native enzyme, pH 7.4 | Homo sapiens | |
1.2.1.3 | 0.074 | - |
NAD+ | native enzyme, pH 9.0 | Rattus norvegicus | |
1.2.1.3 | 0.09 | - |
NAD+ | mutant enzyme E487Q | Homo sapiens | |
1.2.1.3 | 0.7 | - |
NAD+ | mutant enzyme E487K, pH 7.4 | Rattus norvegicus | |
1.2.1.3 | 1.1 | - |
NAD+ | mutant enzyme E487K, pH 9.0 | Rattus norvegicus | |
1.2.1.3 | 7.4 | - |
NAD+ | mutant enzyme E487K | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.3 | Homo sapiens | - |
- |
- |
1.2.1.3 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.3 | - |
Homo sapiens |
1.2.1.3 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.3 | acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
1.2.1.3 | acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
1.2.1.3 | chloroacetaldehyde + NAD+ + H2O | activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K | Homo sapiens | chloroacetate + NADH + H+ | - |
? | |
1.2.1.3 | chloroacetaldehyde + NAD+ + H2O | activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K | Rattus norvegicus | chloroacetate + NADH + H+ | - |
? | |
1.2.1.3 | propanal + NAD+ + H2O | - |
Homo sapiens | propionate + NADH | - |
? | |
1.2.1.3 | propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.3 | additional information | - |
additional information | - |
Homo sapiens | |
1.2.1.3 | additional information | - |
additional information | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | NAD+ | - |
Homo sapiens | |
1.2.1.3 | NAD+ | - |
Rattus norvegicus |