EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.1.3 | R264E | turnover-number is about 6% of that of the native enzyme, Km-value is about 20fold higher than the Km-value of the wild-type enzyme | Homo sapiens |
1.2.1.3 | R264Q | turnover-number is about 50% of that of the native enzyme, Km-value is about 1.6fold higher than the Km-value of the wild-type enzyme | Homo sapiens |
1.2.1.3 | R475E | turnover-number is about 9% of that of the native enzyme, Km-value is about 35fold higher than the Km-value of the wild-type enzyme | Homo sapiens |
1.2.1.3 | R475E/R264E | turnover-number is about 2% of that of the native enzyme, Km-value is about 430fold higher than the Km-value of the wild-type enzyme | Homo sapiens |
1.2.1.3 | R475Q | positive cooperativity in NAD+ binding, Km-value increases 23fold, mutant enzyme is thermally less stable than the native enzyme, the presence of NAD+ restores nativelike stability to the mutant | Homo sapiens |
1.2.1.3 | R475Q/R264Q | Km-value is about 35fold higher than the KM-value of the wild-type enzyme | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.3 | additional information | - |
additional information | Km-values of the 475 and 264 arginine mutants of Oriental variant E847K | Homo sapiens | |
1.2.1.3 | 0.037 | - |
NAD+ | native enzyme | Homo sapiens | |
1.2.1.3 | 0.06 | - |
NAD+ | mutant enzyme R264Q | Homo sapiens | |
1.2.1.3 | 0.74 | - |
NAD+ | mutant enzyme R274E | Homo sapiens | |
1.2.1.3 | 0.85 | - |
NAD+ | mutant enzyme R475Q | Homo sapiens | |
1.2.1.3 | 1.3 | - |
NAD+ | mutant enzyme R475Q/R264Q and R475E | Homo sapiens | |
1.2.1.3 | 16 | - |
NAD+ | mutant enzyme R475E/R264E | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.3 | mitochondrion | enzyme ALDH-2 | Homo sapiens | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | Mg2+ | activates | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.3 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.3 | propanal + NAD+ + H2O | - |
Homo sapiens | propionate + NADH | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.3 | 40 | - |
1 min, mutant enzyme R475Q loses 50% of its activity | Homo sapiens |
1.2.1.3 | 50 | - |
2 min, complete loss of activity of mutant enzyme R475Q, native enzyme loses 10% of itst activity | Homo sapiens |
1.2.1.3 | 55 | - |
1 min, 50% loss of activity of native enzyme | Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.3 | additional information | - |
additional information | turnover numbers of the 475 and 264 arginine mutants of Oriental variant E847K | Homo sapiens | |
1.2.1.3 | 0.0667 | - |
NAD+ | mutant enzyme R475E/R264E | Homo sapiens | |
1.2.1.3 | 0.2 | - |
NAD+ | mutant enzyme R264E | Homo sapiens | |
1.2.1.3 | 0.3 | - |
NAD+ | mutant enzyme R475E | Homo sapiens | |
1.2.1.3 | 2 | - |
NAD+ | mutant enzyme R475Q | Homo sapiens | |
1.2.1.3 | 2.08 | - |
NAD+ | mutant enzyme R264Q | Homo sapiens | |
1.2.1.3 | 3.5 | - |
NAD+ | native enzyme | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | NAD+ | - |
Homo sapiens |