Any feedback?
Literature summary extracted from
- Specific and non-specific binding of long-chain fatty acids to firefly luciferase: cutoff at octanate (1999), Biochim. Biophys. Acta, 1426, 143-150.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.12.7 | butanoic acid | IC50: 13.6 mM | Photinus pyralis |  |
| 1.13.12.7 | Decanoic acid | IC50: 0.0132 mM | Photinus pyralis | |
| 1.13.12.7 | dodecanoic acid | IC50: 0.0012 mM | Photinus pyralis | |
| 1.13.12.7 | hexadecanoic acid | IC50: 0.00067 mM | Photinus pyralis | |
| 1.13.12.7 | hexanoic acid | IC50: 3.4 mM | Photinus pyralis | |
| 1.13.12.7 | octadecanoic acid | IC50: 0.00063 mM | Photinus pyralis | |
| 1.13.12.7 | octanoic acid | IC50: 2.9 mM | Photinus pyralis | |
| 1.13.12.7 | tetradecanoic acid | IC50: 0.00068 mM | Photinus pyralis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.7 | luciferin + O2 + ATP | Photinus pyralis | - |
oxyluciferin + AMP + diphosphate + CO2 + light | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.12.7 | Photinus pyralis | - |
firefly | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.7 | luciferin + O2 + ATP | - |
Photinus pyralis | oxyluciferin + AMP + diphosphate + CO2 + light | - |
ir | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.13.12.7 | 0.00063 | - |
IC50: 0.00063 mM | Photinus pyralis | octadecanoic acid | |
| 1.13.12.7 | 0.00067 | - |
IC50: 0.00067 mM | Photinus pyralis | hexadecanoic acid | |
| 1.13.12.7 | 0.00068 | - |
IC50: 0.00068 mM | Photinus pyralis | tetradecanoic acid | |
| 1.13.12.7 | 0.0012 | - |
IC50: 0.0012 mM | Photinus pyralis | dodecanoic acid | |
| 1.13.12.7 | 0.0132 | - |
IC50: 0.0132 mM | Photinus pyralis | Decanoic acid | |
| 1.13.12.7 | 2.9 | - |
IC50: 2.9 mM | Photinus pyralis | octanoic acid | |
| 1.13.12.7 | 3.4 | - |
IC50: 3.4 mM | Photinus pyralis | hexanoic acid | |
| 1.13.12.7 | 13.6 | - |
IC50: 13.6 mM | Photinus pyralis | butanoic acid | |
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Release 2023.1 (January 2023)
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