Any feedback?
Literature summary extracted from
- Characterization of liver flavin-containing monooxygenase of the dogfish shark (Squalus acanthias) and partial purification of liver flavin-containing monooxygenase of the silky shark (Carcharhinus falciformis) (1994), Comp. Biochem. Physiol. B, 109, 655-664.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | Methimazole | not competitive; oxidation of dimethylaniline | Squalus acanthias |  |
| 1.14.13.8 | thiobenzamide | oxidation of dimethylaniline, competitive | Squalus acanthias | |
| 1.14.13.8 | trimethylamine | 1 mM, oxidation of dimethylaniline, competitive | Squalus acanthias | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.8 | 0.044 | - |
N,N-Dimethylaniline | - |
Squalus acanthias | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.8 | microsome | - |
Squalus acanthias | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 50000 | - |
Western blot, anti-FMO 2 antisera | Squalus acanthias |
| 1.14.13.8 | 50000 | - |
Western blot, anti-FMO 2 antisera | Carcharhinus falciformis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Carcharhinus falciformis | - |
silky shark | - |
| 1.14.13.8 | Squalus acanthias | - |
dogfish shark | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.13.8 | partial | Carcharhinus falciformis |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | methimazole + NADPH + O2 | - |
Squalus acanthias | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + H+ + O2 | - |
Squalus acanthias | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
r | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Squalus acanthias | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 25 | - |
- |
Squalus acanthias |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 15 | 45 | 15°C, 76% loss of activity, 45°C 99% loss of activity | Squalus acanthias |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 9.6 | - |
- |
Squalus acanthias |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
