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Literature summary extracted from
- Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and rat (1985), Arch. Biochem. Biophys., 240, 77-93.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | n-octylamine | - |
Sus scrofa |  |
| 1.14.13.8 | n-octylamine | allosteric activation of pig liver and mouse lung enzymes, not mouse, rabbit or rat liver enzymes | Mus musculus | |
| 1.14.13.8 | n-octylamine | allosteric activation of pig liver and mouse lung enzymes, not mouse, rabbit or rat liver enzymes | Rattus norvegicus | |
| 1.14.13.8 | n-octylamine | allosteric activation of pig liver and mouse lung enzymes, not mouse, rabbit or rat liver enzymes | Oryctolagus cuniculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.8 | additional information | - |
additional information | - |
Mus musculus | |
| 1.14.13.8 | additional information | - |
additional information | - |
Rattus norvegicus | |
| 1.14.13.8 | additional information | - |
additional information | - |
Sus scrofa | |
| 1.14.13.8 | additional information | - |
additional information | - |
Oryctolagus cuniculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Mus musculus | - |
- |
- |
| 1.14.13.8 | Oryctolagus cuniculus | - |
- |
- |
| 1.14.13.8 | Rattus norvegicus | - |
- |
- |
| 1.14.13.8 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | kidney | - |
Mus musculus | - |
| 1.14.13.8 | kidney | - |
Rattus norvegicus | - |
| 1.14.13.8 | kidney | - |
Oryctolagus cuniculus | - |
| 1.14.13.8 | liver | - |
Mus musculus | - |
| 1.14.13.8 | liver | - |
Rattus norvegicus | - |
| 1.14.13.8 | liver | - |
Sus scrofa | - |
| 1.14.13.8 | liver | - |
Oryctolagus cuniculus | - |
| 1.14.13.8 | lung | - |
Mus musculus | - |
| 1.14.13.8 | lung | - |
Rattus norvegicus | - |
| 1.14.13.8 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | 1-butanethiol + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | 1-butanethiol + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | 1-butanethiol + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | 1-butanethiol + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | 2-mercaptobenzimidazole + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | 2-mercaptobenzimidazole + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | 2-mercaptobenzimidazole + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | 2-mercaptobenzimidazole + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | alpha-naphthylthiourea + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | alpha-naphthylthiourea + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | alpha-naphthylthiourea + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | alpha-naphthylthiourea + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | aminopyrine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | aminopyrine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | aminopyrine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | aminopyrine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | cysteamine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | cysteamine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | cysteamine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | cysteamine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | dibenzylamine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | dibenzylamine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | dibenzylamine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | dibenzylamine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | ephedrine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | ephedrine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | ephedrine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | ephedrine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | ethylene sulfide + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | ethylene sulfide + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | ethylene sulfide + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | ethylene sulfide + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | imipramine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | imipramine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | imipramine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | imipramine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | methamphetamine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | methamphetamine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | methamphetamine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | methamphetamine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | methimazole + NADPH + O2 | - |
Mus musculus | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| 1.14.13.8 | methimazole + NADPH + O2 | - |
Rattus norvegicus | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| 1.14.13.8 | methimazole + NADPH + O2 | - |
Sus scrofa | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| 1.14.13.8 | methimazole + NADPH + O2 | - |
Oryctolagus cuniculus | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| 1.14.13.8 | methylphenylsulfide + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | methylphenylsulfide + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | methylphenylsulfide + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | methylphenylsulfide + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | additional information | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | additional information | overview on specificity | Mus musculus | ? | - |
? | |
| 1.14.13.8 | additional information | overview on specificity | Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | additional information | overview on specificity | Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Mus musculus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Rattus norvegicus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Sus scrofa | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Oryctolagus cuniculus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | N-aminopiperidine + NADPH + O2 | - |
Mus musculus | tetrazene + NADP+ + H2O + ? | - |
? | |
| 1.14.13.8 | N-aminopiperidine + NADPH + O2 | - |
Rattus norvegicus | tetrazene + NADP+ + H2O + ? | - |
? | |
| 1.14.13.8 | N-aminopiperidine + NADPH + O2 | - |
Sus scrofa | tetrazene + NADP+ + H2O + ? | - |
? | |
| 1.14.13.8 | p-chloro-N-methylaniline + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | p-chloro-N-methylaniline + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | p-chloro-N-methylaniline + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | p-chloro-N-methylaniline + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | phenylthiourea + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | phenylthiourea + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | phenylthiourea + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | phenylthiourea + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | thioacetamide + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | thioacetamide + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | thioacetamide + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | thioacetamide + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | thiobenzamide + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | thiobenzamide + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | thiobenzamide + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | thiourea + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | thiourea + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | thiourea + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | thiourea + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.14.13.8 | trimethylamine + NADPH + O2 | - |
Mus musculus | ? | - |
? | |
| 1.14.13.8 | trimethylamine + NADPH + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.13.8 | trimethylamine + NADPH + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.13.8 | trimethylamine + NADPH + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | 8.8 | - |
- |
Mus musculus |
| 1.14.13.8 | 9 | - |
- |
Mus musculus |
| 1.14.13.8 | 9.8 | - |
- |
Mus musculus |
| 1.14.13.8 | 9.8 | - |
- |
Rattus norvegicus |
| 1.14.13.8 | 9.8 | - |
- |
Oryctolagus cuniculus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.8 | additional information | - |
- |
Mus musculus |
| 1.14.13.8 | additional information | - |
- |
Rattus norvegicus |
| 1.14.13.8 | additional information | - |
- |
Oryctolagus cuniculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | FAD | flavoprotein | Mus musculus | |
| 1.14.13.8 | FAD | flavoprotein | Rattus norvegicus | |
| 1.14.13.8 | FAD | flavoprotein | Sus scrofa | |
| 1.14.13.8 | FAD | flavoprotein | Oryctolagus cuniculus | |
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