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Literature summary extracted from
- Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes (1966), Biochemistry, 5, 2932-2938.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | 2-diethylaminoethyl-2,2-diphenylpentanoate | SKF-525A, inhibition of dealkylation | Sus scrofa |  |
| 1.14.13.8 | CO | inhibition of dealkylation | Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | additional information | reaction can be functionally separated into 2 partial reactions: 1. a reduced pyridine nucleotide and oxygen-dependent N-oxide synthase, 2. an N-oxide dealkylase | Sus scrofa | ? | - |
? | |
| 1.14.13.8 | N,N-dimethylaniline + NADPH + O2 | - |
Sus scrofa | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | NADH | can partially replace NADPH | Sus scrofa | |
| 1.14.13.8 | NADPH | - |
Sus scrofa | |
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