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Literature summary extracted from

  • Tegoni, M.; Janot, J.M.; Labeyrie, F.
    Inhibition of L-lactate: cytochrome-c reductase (flavocytochrome b2) by product binding to the semiquinone transient. Loss of reactivity towards monoelectronic acceptors (1990), Eur. J. Biochem., 190, 329-342.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.2.3 pyruvate
-
Saccharomyces cerevisiae
1.1.2.3 pyruvate noncompetitive at low concentrations, uncompetitve at high concentrations Wickerhamomyces anomalus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.2.3 0.4
-
L-lactate
-
Saccharomyces cerevisiae
1.1.2.3 0.4
-
L-lactate
-
Wickerhamomyces anomalus
1.1.2.3 7.4
-
pyruvate
-
Saccharomyces cerevisiae
1.1.2.3 20
-
pyruvate
-
Wickerhamomyces anomalus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.2.3 Fe2+ bound to enzyme Saccharomyces cerevisiae
1.1.2.3 Fe2+ bound to enzyme Wickerhamomyces anomalus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.2.3 (S)-lactate + 2 ferricytochrome c Wickerhamomyces anomalus
-
pyruvate + 2 ferrocytochrome c + 2 H+
-
r
1.1.2.3 (S)-lactate + 2 ferricytochrome c Saccharomyces cerevisiae can feed electrons to respiratory chain at the level of cytochrome c pyruvate + 2 ferrocytochrome c + 2 H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.2.3 Saccharomyces cerevisiae
-
-
-
1.1.2.3 Wickerhamomyces anomalus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.2.3 (S)-lactate + 2 ferricytochrome c
-
Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
r
1.1.2.3 (S)-lactate + 2 ferricytochrome c
-
Wickerhamomyces anomalus pyruvate + 2 ferrocytochrome c + 2 H+
-
r
1.1.2.3 (S)-lactate + 2 ferricytochrome c can feed electrons to respiratory chain at the level of cytochrome c Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
r
1.1.2.3 additional information ferricyanide used as electron acceptor Saccharomyces cerevisiae ?
-
?
1.1.2.3 additional information ferricyanide used as electron acceptor Wickerhamomyces anomalus ?
-
?
1.1.2.3 additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae ?
-
?
1.1.2.3 additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus ?
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.2.3 additional information ferricyanide used as electron acceptor Saccharomyces cerevisiae
1.1.2.3 additional information ferricyanide used as electron acceptor Wickerhamomyces anomalus
1.1.2.3 additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae
1.1.2.3 additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.2.3 2 5 pyruvate
-
Wickerhamomyces anomalus