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Literature summary extracted from
- Prostaglandin dehydrogenase activity of purified rat liver 3alpha-hydroxysteroid dehydrogenase (1987), Biochem. Biophys. Res. Commun., 148, 646-652.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.213 | arachidonic acid | - |
Rattus norvegicus |  |
| 1.1.1.213 | indomethacin | - |
Rattus norvegicus | |
| 1.1.1.213 | non-steroidal anti-inflamatory drug | - |
Rattus norvegicus | |
| 1.1.1.213 | Prostaglandin | A2alpha | Rattus norvegicus | |
| 1.1.1.213 | prostaglandin A2alpha | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.213 | 0.0001 | - |
Prostaglandin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.213 | cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.213 | 34000 | - |
- |
Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.213 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.213 | CaCl2 and ammonium sulfate fractionation, DEAE-cellulose- and hydroxyapatite chromatography, chromatofocusing, Sephadex G-100 | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.213 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.213 | 0.0005 | 0.0053 | for prostaglandins A1, A2, B1, B2, D2, E1, E2, F1, F2alpha at concentrations of 0.06 mM | Rattus norvegicus |
| 1.1.1.213 | 0.0007 | 0.0012 | for 15-keto-prostaglandins E2 and F2alpha at concentrations of 0.06 mM | Rattus norvegicus |
| 1.1.1.213 | 2 | - |
for androsterone | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.213 | additional information | oxidation of 3alpha-hydroxysteroids, secondary alcohols and trans-dihydrodiol proximate carcinogens derived from polycyclic aromatic hydrocarbons, reduction of quinones, aromatic aldehydes and ketones, 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase activity of enzyme | Rattus norvegicus | ? | - |
? | |
| 1.1.1.213 | prostaglandin + NADP+ | types A1, A2, B1, B2, D2, E1, E2, F1, F2alpha and 15-keto-prostaglandinE2 and F2alpha | Rattus norvegicus | ? + NADPH | - |
? | |
| 1.1.1.213 | prostaglandin-F2alpha + NADP+ | - |
Rattus norvegicus | prostaglandin F2 + prostaglandin B2 + NADPH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.213 | monomer | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.213 | 25 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.213 | NADP+ | - |
Rattus norvegicus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.213 | 0.001 | - |
indomethacin | - |
Rattus norvegicus | |
| 1.1.1.213 | 0.003 | - |
prostaglandin A2alpha | - |
Rattus norvegicus | |
| 1.1.1.213 | 0.006 | - |
arachidonic acid | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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