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Literature summary extracted from

  • Heyde, E.; Morrison, J.F.
    Studies on inosine monophosphate dehydrogenase. An associating-dissociating system (1976), Biochim. Biophys. Acta, 429, 635-644.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.205 Reducing agent effectiveness decreases in the order: dithiothreitol, mercaptoethanol, cyanide, ascorbate Klebsiella aerogenes

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 Urea inactive at 3 M but regains activity after dialysis Klebsiella aerogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.205 38000
-
 2 * 38000, amino acid analysis Klebsiella aerogenes
1.1.1.205 86000
-
 smallest active species has a molecular weight of 86000, after polymerization in the absence of reducing agents the largest species has a molecular weight of 248000, gel filtration Klebsiella aerogenes

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Klebsiella aerogenes
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.205
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.205 ? multiples with a basic unit of 160000 Klebsiella aerogenes
1.1.1.205 dimer 2 * 38000, amino acid analysis Klebsiella aerogenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Klebsiella aerogenes