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Literature summary extracted from

  • Buzzee, D.H.; Levin, A.P.
    Demonstration of an effector site for the enzyme inosine 5-phosphate dehydrogenase (1968), Biochem. Biophys. Res. Commun., 30, 673-677.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 GMP feedback inhibitor; feed-back inhibitor eliciting 'allosteric' kinetics of the enzyme, determination of the GMP binding site Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.205 additional information
-
 additional information kinetics Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.205 additional information
-
 additional information Km over the range of pH 7.3-8.5 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.205 0.02
-
 inosine 5'-phosphate pH 7.5, 22°C Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis xanthosine 5'-phosphate + NADH
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.205 partial purification Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.205 partially by ammonium sulfate fractionation Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
 ir
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
 ir
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8 Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 IMP-DH
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.205 IMP:NAD oxidoreductase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.205 inosine 5'-phosphate dehydrogenase
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.205 22
-
 assay at room temperature Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.205 7.5
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.205 5.5 8.8
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 additional information
-
 additional information Ki over the range of pH 7.3 to 8.5 Salmonella enterica subsp. enterica serovar Typhimurium