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Literature summary extracted from

  • Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.
    Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis (1992), Biochim. Biophys. Acta, 1116, 50-56.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 p-hydroxymercuribenzoate
-
 Homo sapiens
1.1.1.184 quercitrin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.05 0.07 menadione Km depending on enzyme form Homo sapiens
1.1.1.184 0.14 0.21 Prostaglandin B2 Km depending on enzyme form Homo sapiens
1.1.1.184 0.15
-
 5alpha-androstane-3,17-dione form CR2 Homo sapiens
1.1.1.184 0.24
-
 prostaglandin E2 form CR2 Homo sapiens
1.1.1.184 0.31 0.45 4-benzoylpyridine Km depending on enzyme form Homo sapiens
1.1.1.184 0.38 0.65 4-formylbenzoic acid Km depending on enzyme form Homo sapiens
1.1.1.184 0.49 2 pyridine-4-carboxaldehyde Km depending on enzyme form Homo sapiens
1.1.1.184 1.3 1.6 4-nitrobenzaldehyde Km depending on enzyme form Homo sapiens
1.1.1.184 1.3 2.5 4-Nitroacetophenone Km depending on enzyme form Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.184 3 forms from testis: CR1, CR2, CR3 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 4-benzoylpyridine + NADPH
-
 Homo sapiens ?
-
 ?
1.1.1.184 4-carboxybenzaldehyde + NADPH
-
 Homo sapiens 4-carboxybenzyl alcohol + NADP+
-
 ?
1.1.1.184 4-nitroacetophenone + NADPH
-
 Homo sapiens ?
-
 ?
1.1.1.184 4-nitrobenzaldehyde + NADPH
-
 Homo sapiens 4-nitrobenzyl alcohol + NADP+
-
 ?
1.1.1.184 5alpha-androstane-3,17-dione + NADPH only enzyme forms CR2, CR8 Homo sapiens ?
-
 ?
1.1.1.184 5beta-androstan-17beta-ol-3-one + NADPH only enzyme forms CR2, CR8 Homo sapiens ?
-
 ?
1.1.1.184 menadione + NADPH
-
 Homo sapiens ?
-
 ?
1.1.1.184 prostaglandin B2 + NADPH
-
 Homo sapiens ?
-
 ?
1.1.1.184 prostaglandin E2 + NADPH only enzyme forms CR2, CR8 Homo sapiens ?
-
 ?
1.1.1.184 pyridine-4-carboxaldehyde + NADPH
-
 Homo sapiens ?
-
 ?