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Literature summary extracted from

  • Lipke, H.; Kearns, C.W.
    DDT dehydrochlorinase. II. Substrate and cofactor specificity (1959), J. Biol. Chem., 234, 2129-2132.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.5.1.1 cysteinylglycine activates Musca domestica

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.5.1.1 iodoacetate inhibition to a minor degree, completely reversible Musca domestica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.5.1.1 Al3+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Ca2+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Cu2+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Fe2+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Mg2+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Mn2+ stimulates at a concentration of 0.1 mM Musca domestica
4.5.1.1 Zn2+ stimulates at a concentration of 0.1 mM Musca domestica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.5.1.1 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane Musca domestica
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.5.1.1 Musca domestica
-
 DDT-restistant housedly
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.5.1.1 1,1,1-trichloro-2,2-bis(4-bromophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica ?
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-fluorophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-iodophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
4.5.1.1 1,1,1-trichloro-2,2-bis(4-tolyl)ethane
-
 Musca domestica ? + HCl
-
 ?
4.5.1.1 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane i.e. TDE, reaction velocity is 4 times the rate of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane, i.e. DDT Musca domestica 1-chloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?