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Literature summary extracted from
- Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4 (1995), J. Biol. Chem., 270, 180-188.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | alpha-ketoglutarate | activates | Rattus norvegicus |  |
| 4.4.1.13 | additional information | several other alpha-keto acids also stimulate | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | aminooxyacetic acid | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.13 | 50000 | - |
x * 50000, x * 70000, SDS-PAGE | Rattus norvegicus |
| 4.4.1.13 | 70000 | - |
x * 50000, x * 70000, SDS-PAGE | Rattus norvegicus |
| 4.4.1.13 | 330000 | - |
nondenaturing PAGE | Rattus norvegicus |
| 4.4.1.13 | 330000 | - |
high molecular weight lyase, in rat kidney mitochondria and cytosol | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.13 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.4.1.13 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.13 | kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.13 | 5'-S-cysteinyldopamine | - |
Rattus norvegicus | ? | - |
? | |
| 4.4.1.13 | leukotriene E4 | - |
Rattus norvegicus | ? | - |
? | |
| 4.4.1.13 | S-(1,1,2,2-tetrafluoroethyl)-L-cysteine | - |
Rattus norvegicus | ? | - |
? | |
| 4.4.1.13 | S-(1,2-dichloroethenyl)-L-cysteine + H2O | - |
Rattus norvegicus | pyruvate + NH3 + dichlorovinyl mercaptane | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.4.1.13 | oligomer | x * 50000, x * 70000, SDS-PAGE | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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