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Literature summary extracted from
- Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs (1978), J. Biol. Chem., 253, 8854-8859.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | hydroxylamine | - |
Rattus norvegicus |  |
| 4.4.1.13 | KCN | no efffect | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.13 | 0.5 | - |
2,4-dinitrophenyl-L-cysteine | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | additional information | MgCl2 | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.13 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.4.1.13 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.13 | kidney | - |
Rattus norvegicus | - |
| 4.4.1.13 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.13 | additional information | - |
- |
Rattus norvegicus |
| 4.4.1.13 | 0.0314 | - |
- |
Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.4.1.13 | -20°C, 10 days, no loss of activity | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.13 | (S)-2,4-dinitrophenyl-L-cysteine | - |
Rattus norvegicus | 2,4-dinitrobenzenethiol + pyruvate + NH3 | - |
? | |
| 4.4.1.13 | 2,4-dinitrophenyl-L-cysteine + H2O | - |
Rattus norvegicus | 2,4-dinitrobenzenethiol + pyruvate + NH3 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.13 | 7.6 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.13 | 5.5 | 8 | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.13 | additional information | no cofactor requirement | Rattus norvegicus | |
| 4.4.1.13 | pyridoxal 5'-phosphate | no effect | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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