EC Number | Application | Comment | Organism |
---|---|---|---|
3.7.1.3 | medicine | NAD+ biosynthesis | Rattus norvegicus |
EC Number | General Stability | Organism |
---|---|---|
4.4.1.13 | pyridoxal 5'-phosphate stabilizes | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.13 | 3-hydroxykynurenine | cysteine conjugate beta-lyase activity | Rattus norvegicus | |
4.4.1.13 | hydroxylamine | - |
Rattus norvegicus | |
4.4.1.13 | KCN | - |
Rattus norvegicus | |
4.4.1.13 | kynurenine | cysteine conjugate beta-lyase activity | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.7.1.3 | 0.013 | - |
L-3-hydroxykynurenine | - |
Rattus norvegicus | |
3.7.1.3 | 0.4 | - |
L-kynurenine | - |
Rattus norvegicus | |
4.4.1.13 | 0.013 | - |
3-hydroxy-kynurenine | - |
Rattus norvegicus | |
4.4.1.13 | 0.4 | - |
kynurenine | - |
Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.7.1.3 | 55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
4.4.1.13 | 55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | Rattus norvegicus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3.7.1.3 | L-kynurenine + H2O | Rattus norvegicus | - |
anthranilate + L-alanine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.7.1.3 | Rattus norvegicus | - |
- |
- |
4.4.1.13 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.7.1.3 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.7.1.3 | liver | - |
Rattus norvegicus | - |
4.4.1.13 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.7.1.3 | 0.25 | - |
- |
Rattus norvegicus |
4.4.1.13 | 0.0817 | - |
- |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3.7.1.3 | L-kynurenine + H2O | - |
Rattus norvegicus | anthranilate + L-alanine | - |
? | |
4.4.1.13 | 3-hydroxykynurenine | - |
Rattus norvegicus | ? | - |
? | |
4.4.1.13 | kynurenine | - |
Rattus norvegicus | ? | - |
? | |
4.4.1.13 | xenobiotics | - |
Rattus norvegicus | thiol + pyruvate + NH3 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.7.1.3 | dimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
4.4.1.13 | dimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.4.1.13 | More | rat liver enzyme: same enzyme as kynureninase | Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.4.1.13 | 70 | - |
50% loss of activity after 10 min | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
3.7.1.3 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
4.4.1.13 | pyridoxal 5'-phosphate | - |
Rattus norvegicus |