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Literature summary extracted from

  • Brand, L.M.; Lowenstein, J.M.
    Inhibition of adenylosuccinase by adenylophosphonopropionate and related compounds (1978), Biochemistry, 17, 1365-1370.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.3.2.2 three cycles of freezing and thawing remove nearly all enzyme activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.2 adenosine phosphonobutyric, 2'(3'), 5'-diposphate
-
 Rattus norvegicus
4.3.2.2 adenyloethylphosphonate
-
 Rattus norvegicus
4.3.2.2 DL-3-phosphonoalanine
-
 Rattus norvegicus
4.3.2.2 L-Asp
-
 Rattus norvegicus
4.3.2.2 mercaptopurinosuccinate substrate inhibition Rattus norvegicus
4.3.2.2 N6-(2-carboxyethyl)-AMP i.e. adenylopropionate Rattus norvegicus
4.3.2.2 N6-(D-1,2-dicarboxyethyl)-AMP i.e. D-adenylosuccinate Rattus norvegicus
4.3.2.2 N6-(DL-1,2-dicarboxy-threo-2-hydroxyethyl)-AMP i.e. adenylomalate Rattus norvegicus
4.3.2.2 N6-(DL-1-carboxy-2-phosphonoethyl)AMP i.e. adenylophosphonopropionate Rattus norvegicus
4.3.2.2 N6-(L-1,3-dicarboxyprop-1-yl)-AMP i.e. adenyloglutarate Rattus norvegicus
4.3.2.2 N6-(L-1-carboxy-2-cyanoethyl)-AMP i.e. adenylocyanopropionate Rattus norvegicus
4.3.2.2 N6-(L-1-carboxy-2-methylsulfoxyethyl)-AMP i.e. adenylomethylsulfoxypropionate Rattus norvegicus
4.3.2.2 N6-(L-1-carboxy-2-sulfinoethyl)-AMP i.e. adenylosulfinopropionate Rattus norvegicus
4.3.2.2 N6-(L-1-carboxy-2-sulfoethyl)-AMP i.e. adenylosulfopropionate Rattus norvegicus
4.3.2.2 phosphopropionoadenosine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.2 0.0081
-
 4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Rattus norvegicus
4.3.2.2 0.013
-
 N6-(1,2-dicarboxyethyl)AMP
-
 Rattus norvegicus
4.3.2.2 0.02
-
 mercaptopurinosuccinate
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.2 muscle skeletal muscle Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.2 mercaptopurinosuccinate
-
 Rattus norvegicus ?
-
 ?
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP i.e. adenylosuccinate Rattus norvegicus fumarate + AMP
-
 ?