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Literature summary extracted from

  • Drury, E.J.; MacKenzie, R.E.
    Formiminotransferase-cyclodeaminase from porcine liver. A sulfhydryl essential for the deaminase activity of the bifunctional enzyme (1977), Can. J. Biochem., 55, 919-923.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.4 5,5'-dithiobis(2-nitrobenzoate) reversible with dithiothreitol, folate protects Sus scrofa
4.3.1.4 folate
-
 Sus scrofa
4.3.1.4 HgCl2 0.05 mM, triethanolamine-HCl, pH 8.0, 95% loss of activity Sus scrofa
4.3.1.4 additional information
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.4 5-formiminotetrahydrofolate Sus scrofa
-
 ?
-
 ?
4.3.1.4 additional information Sus scrofa folate-dependent bifunctional enzyme formiminoglutamate: tetrahydrofolate formiminotransferase-formiminotetrahydrofolate cyclodeaminase catalyzes two sequential reactions of the histidine degradation pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.4 liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.4 additional information
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.4 5-formiminotetrahydrofolate
-
 Sus scrofa 5,10-methenyltetrahydrofolate + NH3
-
 ?
4.3.1.4 5-formiminotetrahydrofolate
-
 Sus scrofa ?
-
 ?
4.3.1.4 additional information folate-dependent bifunctional enzyme formiminoglutamate: tetrahydrofolate formiminotransferase-formiminotetrahydrofolate cyclodeaminase catalyzes two sequential reactions of the histidine degradation pathway Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.1.4 octamer each of the eight subunits of the formiminotransferase-cyclodeaminase enzyme complex is a bifunctional polypeptide Sus scrofa