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Literature summary extracted from

  • Allen, R.L.; Hopewell, R.; Prottey, C.
    Histidine ammonia-lyase in guinea-pig liver and epidermis (1983), Biochem. Soc. Trans., 11, 349-350.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.3.1.3 GSH increases at concentrations below 5 mM, pH 7.4 Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 5,5'-dithiobis(2-nitrobenzoic acid)
-
 Cavia porcellus
4.3.1.3 dithiothreitol 20 mM, liver and epidermal enzyme, restored by addition with Zn2+ Cavia porcellus
4.3.1.3 EDTA 0.04 mM, liver and epidermal enzyme, restored by incubation with Zn2+ Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.3 0.36
-
 L-histidine pH 9.2 and pH 7.0, epidermal enzyme Cavia porcellus
4.3.1.3 0.55
-
 L-histidine pH 9.2, liver enzyme Cavia porcellus
4.3.1.3 1
-
 L-histidine pH 7.0, liver enzyme Cavia porcellus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.1.3 Zn2+
-
 Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.3 220000
-
 gel-permeation chromatography, liver and epidermis enzyme Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.3 epidermis isoenzyme Cavia porcellus
-
4.3.1.3 epidermis stratum granulosum Cavia porcellus
-
4.3.1.3 epidermis stratum corneum Cavia porcellus
-
4.3.1.3 liver isoenzyme Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 L-histidine natural substrate Cavia porcellus urocanate + NH3
-
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