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Literature summary extracted from

  • Poston, J.M.
    beta-Leucine and the beta-keto pathway of leucine metabolism (1986), Adv. Enzymol. Relat. Areas Mol. Biol., 58, 173-189.
    View publication on PubMed

General Stability

EC Number General Stability Organism
5.4.3.7 enzyme in crude extract is stable to freezing and thawing Clostridium sporogenes

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.3.7 cytosol in liver Rattus norvegicus 5829
-
5.4.3.7 mitochondrion activity is 100fold lower than in cytosol of liver Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.3.7 beta-Leu Homo sapiens enzyme is involved in the synthesis of Leu from Val catabolites ?
-
 ?
5.4.3.7 beta-Leu Rattus norvegicus enzyme is involved in the synthesis of Leu from Val catabolites ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.3.7 Andrographis paniculata
-
-
-
5.4.3.7 Clostridium cochlearium
-
-
-
5.4.3.7 Clostridium sporogenes
-
-
-
5.4.3.7 Cyberlindnera jadinii
-
-
-
5.4.3.7 Homo sapiens
-
-
-
5.4.3.7 Lolium sp.
-
-
-
5.4.3.7 Phaseolus vulgaris
-
-
-
5.4.3.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.3.7 brain
-
 Rattus norvegicus
-
5.4.3.7 heart
-
 Rattus norvegicus
-
5.4.3.7 kidney
-
 Rattus norvegicus
-
5.4.3.7 liver
-
 Homo sapiens
-
5.4.3.7 liver
-
 Rattus norvegicus
-
5.4.3.7 skeletal muscle high activity Rattus norvegicus
-
5.4.3.7 small intestine very low activity Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.3.7 alpha-Leu
-
 Cyberlindnera jadinii beta-Leu
-
 ?
5.4.3.7 alpha-Leu
-
 Homo sapiens beta-Leu
-
 ?
5.4.3.7 alpha-Leu
-
 Rattus norvegicus beta-Leu
-
 ?
5.4.3.7 alpha-Leu
-
 Andrographis paniculata beta-Leu
-
 ?
5.4.3.7 alpha-Leu
-
 Clostridium cochlearium beta-Leu
-
 ?
5.4.3.7 alpha-Leu
-
 Lolium sp. beta-Leu
-
 ?
5.4.3.7 alpha-Leu r Phaseolus vulgaris beta-Leu
-
 ?
5.4.3.7 alpha-Leu r Clostridium sporogenes beta-Leu
-
 ?
5.4.3.7 beta-Leu enzyme is involved in the synthesis of Leu from Val catabolites Homo sapiens ?
-
 ?
5.4.3.7 beta-Leu enzyme is involved in the synthesis of Leu from Val catabolites Rattus norvegicus ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
5.4.3.7 60
-
 10 min stable, enzyme in crude extract Clostridium sporogenes

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.3.7 Cobalamin not dependent on Andrographis paniculata
5.4.3.7 cobamide i.e. adenosylcobalamin, required Clostridium sporogenes