BRENDA - Enzyme Database show

Pyridine and piperidine derivatives as inhibitors of dihydrdipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to L-lysine

Couper, L.; McKendrick, J.E.; Robins, D.J.; Bioorg. Med. Chem. Lett. 4, 2267-2272 (1994)
No PubMed abstract available

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.3.3.7
expression in Escherichia coli
Escherichia coli
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.3.7
cis-piperidine-2,6-dicarboxylic acid
and derivatives
Escherichia coli
4.3.3.7
dipicolinic acid
1 mM, 50% inhibition
Escherichia coli
4.3.3.7
dipicolinic acid di-imidate
-
Escherichia coli
4.3.3.7
dipicolinic acid N-oxide
0.8 mM 50% inhibition
Escherichia coli
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.3.3.7
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
L-aspartate-4-semialdehyde + pyruvate
-
33918
Escherichia coli
dihydrodipicolinate + H2O
-
33918
Escherichia coli
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.3.3.7
0.8
-
dipicolinic acid N-oxide
-
Escherichia coli
4.3.3.7
1
-
dipicolinic acid
-
Escherichia coli
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.3.3.7
expression in Escherichia coli
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.3.7
cis-piperidine-2,6-dicarboxylic acid
and derivatives
Escherichia coli
4.3.3.7
dipicolinic acid
1 mM, 50% inhibition
Escherichia coli
4.3.3.7
dipicolinic acid di-imidate
-
Escherichia coli
4.3.3.7
dipicolinic acid N-oxide
0.8 mM 50% inhibition
Escherichia coli
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.3.3.7
0.8
-
dipicolinic acid N-oxide
-
Escherichia coli
4.3.3.7
1
-
dipicolinic acid
-
Escherichia coli
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
L-aspartate-4-semialdehyde + pyruvate
-
33918
Escherichia coli
dihydrodipicolinate + H2O
-
33918
Escherichia coli
?