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Literature summary extracted from
- A single cyclohexadienyl dehydratase specifies the prephenate dehydratase and arogenate dehydratase components of one of two independent pathways to L-phenylalanine in Erwinia herbicola (1991), Arch. Biochem. Biophys., 286, 461-465.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.91 | L-arogenate | competitive inhibition of prephenate dehydratase activity | Pantoea agglomerans |  |
| 4.2.1.91 | prephenate | competitive inhibition | Pantoea agglomerans | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.51 | 0.17 | - |
prephenate | - |
Pantoea agglomerans | |
| 4.2.1.91 | 0.09 | - |
L-arogenate | pH 7.2, 37°C, 0.01 mM tyrosine | Pantoea agglomerans | |
| 4.2.1.91 | 0.17 | - |
prephenate | pH 7.2, 37°C | Pantoea agglomerans | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.51 | 18000 | - |
4 * 18000, bifunctional enzyme prephenate dehydratase-arogenate dehydratase, SDS-PAGE | Pantoea agglomerans |
| 4.2.1.51 | 73000 | - |
bifunctional enzyme, prephenate dehydratase-arogenate dehydratase, gel filtration | Pantoea agglomerans |
| 4.2.1.91 | 18000 | - |
4 * 18000, SDS-PAGE | Pantoea agglomerans |
| 4.2.1.91 | 73000 | - |
gel filtration | Pantoea agglomerans |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.51 | prephenate | Pantoea agglomerans | - |
? | - |
? | |
| 4.2.1.91 | L-arogenate | Pantoea agglomerans | - |
L-phenylalanine + CO2 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.51 | Pantoea agglomerans | - |
- |
- |
| 4.2.1.91 | Pantoea agglomerans | - |
ATCC 33243 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.51 | bifunctional enzyme, prephenate dehydratase-arogenate dehydratase | Pantoea agglomerans |
| 4.2.1.91 | - |
Pantoea agglomerans |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.51 | 29.4 | - |
- |
Pantoea agglomerans |
| 4.2.1.91 | 23.68 | - |
L-arogenate dehydratase activity | Pantoea agglomerans |
| 4.2.1.91 | 29.4 | - |
prephenate dehydratase activity | Pantoea agglomerans |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.51 | prephenate | - |
Pantoea agglomerans | phenylpyruvate + H2O + CO2 | - |
? | |
| 4.2.1.51 | prephenate | - |
Pantoea agglomerans | ? | - |
? | |
| 4.2.1.91 | L-arogenate | - |
Pantoea agglomerans | L-phenylalanine + CO2 + H2O | - |
? | |
| 4.2.1.91 | prephenate | - |
Pantoea agglomerans | phenylpyruvate + CO2 + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.51 | tetramer | 4 * 18000, bifunctional enzyme prephenate dehydratase-arogenate dehydratase, SDS-PAGE | Pantoea agglomerans |
| 4.2.1.91 | tetramer | 4 * 18000, SDS-PAGE | Pantoea agglomerans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.91 | CDT | - |
Pantoea agglomerans |
| 4.2.1.91 | cyclohexadienyl dehydratase | - |
Pantoea agglomerans |
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