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Literature summary extracted from

  • Gardner, P.R.; Fridovich, I.
    Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase (1991), J. Biol. Chem., 266, 1478-1483.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.12 H2O2 the enzyme is much less sensitive to O2 or H2O2 than to O2- Escherichia coli
4.2.1.12 O2 the enzyme is much less sensitive to O2 or H2O2 than to O2- Escherichia coli
4.2.1.12 O2- the O2--sensitive target site is proposed to be an iron-sulfur cluster which is readily destroyed by oxidation Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.12 Iron enzyme contains iron-sulfur clusters Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.12 Escherichia coli
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
4.2.1.12 F- stabilizes and blocks the efect of oxidants Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.12 6-phospho-D-gluconate
-
 Escherichia coli 6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
-
 ?