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Literature summary extracted from
- Catalysis and inhibition of human carbonic anhydrase IV (1997), Biochemistry, 36, 2669-2678.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | Br- | below 20 mM, activates | Homo sapiens |  |
| 4.2.1.1 | Cl- | below 20 mM, activates | Homo sapiens | |
| 4.2.1.1 | phosphate | below 20 mM, activates | Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | Sulfonamides | affinity of carbonic anhydrase IV for sulfonamides is decreased up to 65fold compared to carbonic anhydrase II | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 8 | - |
CO2 | carbonic anhydrase II | Homo sapiens | |
| 4.2.1.1 | 22 | - |
CO2 | carbonic anhydrase IV | Homo sapiens | |
| 4.2.1.1 | 26 | - |
HCO3- | carbonic anhydrase IV | Homo sapiens | |
| 4.2.1.1 | 37 | - |
HCO3- | carbonic anhydrase II | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.1.1 | membrane | bound | Homo sapiens | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Homo sapiens | - |
carbonic anhydrase IV | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | side-chain modification | phospholipid anchor may be acting both as an extracellular tether and as a protein activator | Homo sapiens |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.2.1.1 | H2CO3 = CO2 + H2O | mechanism | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | kidney | carbonic anhydrase IV | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | additional information | - |
additional information | - |
Homo sapiens | |
| 4.2.1.1 | 18300 | - |
CO2 | pH-independent turnover | Homo sapiens | |
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