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Literature summary extracted from
- Inhibition and kinetic properties of membrane-bound carbonic anhydrases in rabbit skeletal muscles (1998), Arch. Biochem. Biophys., 356, 151-158.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | acetazolamide | - |
Oryctolagus cuniculus |  |
| 4.2.1.1 | benzolamide | - |
Oryctolagus cuniculus | |
| 4.2.1.1 | chlorzolamide | - |
Oryctolagus cuniculus | |
| 4.2.1.1 | ethoxyzolamide | - |
Oryctolagus cuniculus | |
| 4.2.1.1 | methazolamide | - |
Oryctolagus cuniculus | |
| 4.2.1.1 | OCN- | - |
Oryctolagus cuniculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 1.6 | - |
CO2 | enzyme from white muscle sarcoplasmic reticulum | Oryctolagus cuniculus | |
| 4.2.1.1 | 2.4 | - |
CO2 | - |
Oryctolagus cuniculus | |
| 4.2.1.1 | 3.6 | - |
CO2 | enzyme from red muscle sarcolemmal membranes | Oryctolagus cuniculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.1.1 | sarcolemma | associated with | Oryctolagus cuniculus | 42383 | - |
| 4.2.1.1 | sarcoplasmic reticulum | associated with | Oryctolagus cuniculus | 16529 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | muscle | skeletal muscle | Oryctolagus cuniculus | - |
| 4.2.1.1 | muscle | white muscle and red muscle | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | CO2 + H2O | - |
Oryctolagus cuniculus | H2CO3 | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 3830 | - |
CO2 | enzyme from red muscle sarcoplasmic reticulum | Oryctolagus cuniculus | |
| 4.2.1.1 | 4170 | - |
CO2 | enzyme from red muscle sarcolemmal membranes | Oryctolagus cuniculus | |
| 4.2.1.1 | 6170 | - |
CO2 | enzyme from white muscle sarcoplasmic reticulum | Oryctolagus cuniculus | |
| 4.2.1.1 | 9000 | - |
CO2 | enzyme from white muscle sarcolemmal membranes | Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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