BRENDA - Enzyme Database show

Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis

Haurand, M.; Ullrich, V.; Front. Biotransform. 6, 183-199 (1992)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
2,4-Diamino-6-piperidinopyrimidine-3-oxide
-
Sus scrofa
5.3.99.4
Tranylcypromine
-
Bos taurus
5.3.99.4
Tranylcypromine
-
Sus scrofa
5.3.99.5
CGS 13080
-
Homo sapiens
5.3.99.5
OKY 1581
-
Homo sapiens
5.3.99.5
UK 36248
-
Homo sapiens
5.3.99.5
UK 37,248
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
5.3.99.4
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Sus scrofa
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Bos taurus
-
-
-
5.3.99.4
Sus scrofa
-
-
-
5.3.99.5
Homo sapiens
-
-
-
5.3.99.5
Sus scrofa
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Bos taurus
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Sus scrofa
5.3.99.5
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
mechanism
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
5.3.99.4
aorta
-
Bos taurus
-
5.3.99.5
lung
-
Homo sapiens
-
5.3.99.5
lung
-
Sus scrofa
-
5.3.99.5
platelet
-
Sus scrofa
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
5-trans-Prostaglandin H2
-
3200
Sus scrofa
?
-
-
-
-
5.3.99.4
prostaglandin G2
-
3200
Sus scrofa
prostaglandin I2 + 15-hydroperoxyprostacyclin
-
-
-
-
5.3.99.4
Prostaglandin H2
-
3200
Sus scrofa
Prostaglandin I2
-
-
-
-
5.3.99.4
Prostaglandin H2
-
3200
Bos taurus
Prostaglandin I2
-
-
-
-
5.3.99.4
Prostaglandin H3
-
3200
Sus scrofa
Prostaglandin I3
-
-
-
-
5.3.99.4
Prostaglandin H3
-
3200
Bos taurus
Prostaglandin I3
-
-
-
-
5.3.99.5
15-Ketoprostaglandin H2
-
3200
Homo sapiens
?
-
-
-
-
5.3.99.5
2 prostaglandin G2
i.e. PGG2
3200
Homo sapiens
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
8-Isoprostaglandin H2
-
3200
Homo sapiens
8-cis-12-Hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
prostaglandin H1
-
3200
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
thromboxane B2 is not mentioned as product
3200
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3200
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3200
Sus scrofa
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
3200
Sus scrofa
-
5.3.99.5
Prostaglandin H3
-
3200
Homo sapiens
Thromboxane B3 + DELTA14-12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
pH Stability
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
5.3.99.5
4.5
-
unstable below
Homo sapiens
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
cytochrome P450
cytochrome-P450 enzyme
Sus scrofa
5.3.99.4
cytochrome P450
-
Bos taurus
5.3.99.4
heme
contains 1 heme per 49000 MW polypeptide chain
Sus scrofa
5.3.99.4
heme
-
Bos taurus
5.3.99.5
cytochrome P450
a cytochrome P450 enzyme
Homo sapiens
5.3.99.5
cytochrome P450
-
Sus scrofa
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
cytochrome P450
cytochrome-P450 enzyme
Sus scrofa
5.3.99.4
cytochrome P450
-
Bos taurus
5.3.99.4
heme
contains 1 heme per 49000 MW polypeptide chain
Sus scrofa
5.3.99.4
heme
-
Bos taurus
5.3.99.5
cytochrome P450
a cytochrome P450 enzyme
Homo sapiens
5.3.99.5
cytochrome P450
-
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
2,4-Diamino-6-piperidinopyrimidine-3-oxide
-
Sus scrofa
5.3.99.4
Tranylcypromine
-
Bos taurus
5.3.99.4
Tranylcypromine
-
Sus scrofa
5.3.99.5
CGS 13080
-
Homo sapiens
5.3.99.5
OKY 1581
-
Homo sapiens
5.3.99.5
UK 36248
-
Homo sapiens
5.3.99.5
UK 37,248
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
5.3.99.4
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Sus scrofa
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
5.3.99.4
aorta
-
Bos taurus
-
5.3.99.5
lung
-
Homo sapiens
-
5.3.99.5
lung
-
Sus scrofa
-
5.3.99.5
platelet
-
Sus scrofa
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
5-trans-Prostaglandin H2
-
3200
Sus scrofa
?
-
-
-
-
5.3.99.4
prostaglandin G2
-
3200
Sus scrofa
prostaglandin I2 + 15-hydroperoxyprostacyclin
-
-
-
-
5.3.99.4
Prostaglandin H2
-
3200
Sus scrofa
Prostaglandin I2
-
-
-
-
5.3.99.4
Prostaglandin H2
-
3200
Bos taurus
Prostaglandin I2
-
-
-
-
5.3.99.4
Prostaglandin H3
-
3200
Sus scrofa
Prostaglandin I3
-
-
-
-
5.3.99.4
Prostaglandin H3
-
3200
Bos taurus
Prostaglandin I3
-
-
-
-
5.3.99.5
15-Ketoprostaglandin H2
-
3200
Homo sapiens
?
-
-
-
-
5.3.99.5
2 prostaglandin G2
i.e. PGG2
3200
Homo sapiens
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
8-Isoprostaglandin H2
-
3200
Homo sapiens
8-cis-12-Hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
prostaglandin H1
-
3200
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
thromboxane B2 is not mentioned as product
3200
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3200
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3200
Sus scrofa
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
3200
Sus scrofa
-
5.3.99.5
Prostaglandin H3
-
3200
Homo sapiens
Thromboxane B3 + DELTA14-12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3200
Homo sapiens
-
pH Stability (protein specific)
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
5.3.99.5
4.5
-
unstable below
Homo sapiens