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Literature summary extracted from

  • Haurand, M.; Ullrich, V.
    Thromboxane synthase and prostacyclin synthase as P-450 enzymes with regard to the mechanisms of PGI2 and TXA2 biosynthesis (1992), Front. Biotransform., 6, 183-199.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 2,4-Diamino-6-piperidinopyrimidine-3-oxide
-
 Sus scrofa
5.3.99.4 tranylcypromine
-
 Bos taurus
5.3.99.4 tranylcypromine
-
 Sus scrofa
5.3.99.5 CGS 13080
-
 Homo sapiens
5.3.99.5 OKY 1581
-
 Homo sapiens
5.3.99.5 UK 37,248
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 microsome
-
 Sus scrofa
-
-
5.3.99.4 microsome
-
 Bos taurus
-
-
5.3.99.5 microsome
-
 Homo sapiens
-
-
5.3.99.5 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Bos taurus
-
-
-
5.3.99.4 Sus scrofa
-
-
-
5.3.99.5 Homo sapiens
-
-
-
5.3.99.5 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.3.99.4 (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Sus scrofa
a
5.3.99.4 (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Bos taurus
a
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aorta
-
 Sus scrofa
-
5.3.99.4 aorta
-
 Bos taurus
-
5.3.99.5 lung
-
 Homo sapiens
-
5.3.99.5 lung
-
 Sus scrofa
-
5.3.99.5 platelet
-
 Homo sapiens
-
5.3.99.5 platelet
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 5-trans-Prostaglandin H2
-
 Sus scrofa ?
-
 ?
5.3.99.4 prostaglandin G2
-
 Sus scrofa prostaglandin I2 + 15-hydroperoxyprostacyclin
-
 ?
5.3.99.4 Prostaglandin H2
-
 Sus scrofa Prostaglandin I2
-
 ?
5.3.99.4 Prostaglandin H2
-
 Bos taurus Prostaglandin I2
-
 ?
5.3.99.4 Prostaglandin H3
-
 Sus scrofa Prostaglandin I3
-
 ?
5.3.99.4 Prostaglandin H3
-
 Bos taurus Prostaglandin I3
-
 ?
5.3.99.5 15-Ketoprostaglandin H2
-
 Homo sapiens ?
-
 ?
5.3.99.5 2 prostaglandin G2 + H2O i.e. PGG2 Homo sapiens 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 8-Isoprostaglandin H2
-
 Homo sapiens 8-cis-12-Hydroperoxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 prostaglandin H1
-
 Homo sapiens 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 thromboxane B2 is not mentioned as product ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Sus scrofa thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 Prostaglandin H3
-
 Homo sapiens Thromboxane B3 + DELTA14-12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
 ?

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
5.3.99.5 4.5
-
 unstable below Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.4 cytochrome P450
-
 Bos taurus
5.3.99.4 cytochrome P450 cytochrome-P450 enzyme Sus scrofa
5.3.99.4 heme
-
 Bos taurus
5.3.99.4 heme contains 1 heme per 49000 MW polypeptide chain Sus scrofa
5.3.99.5 cytochrome P450
-
 Sus scrofa
5.3.99.5 cytochrome P450 a cytochrome P450 enzyme Homo sapiens