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Literature summary extracted from

  • Jones, D.A.; Fitzpatrick, F.A.
    "Suicide" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets (1990), J. Biol. Chem., 265, 20166-20171.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 prostaglandin H2 suicide inactivation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.99.5 0.0207
-
 prostaglandin H2
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 microsome
-
 Homo sapiens
-
-
5.3.99.5 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Bos taurus
-
-
-
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.5
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 platelet
-
 Homo sapiens
-
5.3.99.5 platelet
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 prostaglandin H1
-
 Bos taurus 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
 ?
5.3.99.5 prostaglandin H1 poor substrate Homo sapiens 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
 ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Bos taurus thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?