BRENDA - Enzyme Database show

'Suicide' inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets

Jones, D.A.; Fitzpatrick, F.A.; J. Biol. Chem. 265, 20166-20171 (1990)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
prostaglandin H2
suicide inactivation
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.3.99.5
0.0207
-
prostaglandin H2
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Bos taurus
-
-
-
5.3.99.5
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.3.99.5
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Bos taurus
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H1
-
3198
Bos taurus
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
-
5.3.99.5
prostaglandin H1
poor substrate
3198
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3198
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3198
Bos taurus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
prostaglandin H2
suicide inactivation
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
5.3.99.5
0.0207
-
prostaglandin H2
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.5
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Bos taurus
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H1
-
3198
Bos taurus
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
-
5.3.99.5
prostaglandin H1
poor substrate
3198
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
-
-
-
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3198
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3198
Bos taurus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-