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Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives

Kamiya, S.; Matsui, H.; Shirahase, H.; Nakamura, S.; Wada, K.; Kanda, M.; Shimaji, H.; Kakeya, N.; Chem. Pharm. Bull. 43, 1692-1695 (1995)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.5
pharmacology
the thromboxane A2 synthetase inhibitor 1-[3-(4-benzylhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid is a candidate anti-asthmatic drug
Oryctolagus cuniculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
1-[3-(4-Benzylhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid
strong thromboxane synthetase inhibition and H1-blocking activity
Oryctolagus cuniculus
5.3.99.5
N-Substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives
-
Oryctolagus cuniculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Oryctolagus cuniculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3196
Oryctolagus cuniculus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.5
pharmacology
the thromboxane A2 synthetase inhibitor 1-[3-(4-benzylhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid is a candidate anti-asthmatic drug
Oryctolagus cuniculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
1-[3-(4-Benzylhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid
strong thromboxane synthetase inhibition and H1-blocking activity
Oryctolagus cuniculus
5.3.99.5
N-Substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives
-
Oryctolagus cuniculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3196
Oryctolagus cuniculus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-