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Literature summary extracted from

  • Nusing, R.; Schneider-Voss, S.; Ullrich, V.
    Immunoaffinity purification of human thromboxane synthase (1990), Arch. Biochem. Biophys., 280, 325-330.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.99.5 0.01
-
 prostaglandin H2
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.5 58000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.5 one-step immunoaffinity purification Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 platelet
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.99.5 0.255
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1 ?

Subunits

EC Number Subunits Comment Organism
5.3.99.5 ?
-
 Homo sapiens
5.3.99.5 monomer x * 58000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.5 heme hemoprotein Homo sapiens
5.3.99.5 heme contains one heme per 58000 MW protein. The major part of the enzyme is converted by the elution procedure to the inactive P420 form, a minor part is in its native heme-thiolate conformation Homo sapiens